Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. (Q37026573)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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(2S)-2-hydroxy-2-propan-2-ylbutanedioic acid

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trichloroethyl beta-D-glucoside

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4-hydroxy-5-methyl-3(2H)-furanone

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β-pyrazolyl-L-alanine

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dehydro-D-arabinono-1,4-lactone

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3-methyl-2-oxobutyric acid

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4,4'-methylenebis(2-chloroaniline)

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alpha-D-glucosamine 1-phosphate

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3-hydroxybenzenepropanoic acid

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1-salicylate glucuronide

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(R)-3-hydroxybutyric acid

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D-glucuronolactone (open form)

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(3S)-3-methyl-2-oxo-pentanoic acid

2-hydroxyheptanoic acid

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N(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid

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3'-N-debenzoyl-2'-deoxytaxol

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3-(methylthio)propionic acid

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8-hydroxy-7-methylguanine

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indole-3-pyruvic acid

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1,2-Dihexanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)

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5'-S-ethyl-5'-thioadenosine

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(R)-2,3-dihydroxy-3-methylbutanoic acid

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(3E,5E)-tridecadienoic acid

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(5S)-biotin sulfoxide

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4-methylene-L-glutamic acid

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N(2)-succinyl-L-ornithine

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L-cysteine sulphinic acid

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1D-1-O-methyl-myo-inositol

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lysophosphatidic acid 0:0/18:2(9Z,12Z)

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gamma-glutamylcysteine

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D-ribofuranose 5-phosphate

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10-hydroxydecanoic acid

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O-phospho-L-homoserine

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2-deoxy-D-glucose 6-phosphate

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4,4'-sulfonyldiphenol

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1-Octadecyl-2-eicosanoyl-sn-glycero-3-phosphocholine

2-hydroxynonanoic acid

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4-(methylthio)-2-oxobutanoic acid

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gibberellin A8-catabolite

12-hydroxylauric acid

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aspartyl adenylate beta-ketophosphonate isostere

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3-(4-hydroxyphenyl)pyruvic acid

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7,4'-dihydroxy-8,3'-dimethoxyflavanone

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2-hydroxy-3-oxopropanoic acid

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4,4'-isopropylidenediphenol dimethacrylate

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(2S)-2-hydroxy-2-methyl-3-oxobutanoic acid

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5-hydroxyvaleric acid

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4-hydroxy-4-methylglutamic acid

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N-(3-aminopropyl)-N-hydroxyacetamide

phenyl hydrogen sulfate

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18-acetoxy-1alpha-hydroxyvitamin D3

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gibberellin A51-catabolite

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DL-p-hydroxyphenyl lactic acid

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N-acetyl-L-glutamic acid

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O-dodecanedioylcarnitine

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2-C-methylerythritol 4-phosphate

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2-isopropylmaleic acid

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6-acetamido-2-oxohexanoic acid

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2,6-dichloro-4'-biphenylol

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18-acetoxy-1alpha,25-dihydroxyvitamin D3

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(2E,4E,8E,10E)-dodecatetraenedioic acid

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3-hydroxyhexadecanoylcarnitine

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2,2,4-trihydroxybutanoic acid

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(S)-1-pyrroline-5-carboxylic acid

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5-acetamidopentanoic acid

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16-hydroxypalmitic acid

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2,3,5-trihydroxy-4-phosphonooxyadipic acid

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alpha-ketoglutaric acid

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2-(alpha-D-mannosyl)-D-glyceric acid

8-methoxykynurenic acid

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N-phenylacetylglycine

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α-hydroxy myristic acid

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5-hydroxyindole-3-acetic acid

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3-indolepropionic acid

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S-methyl methanethiosulfonate

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dibenzothiophene 5-oxide

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3-sulfopropanoic acid

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6-[2-(2,4-Dihydroxy-6-methylphenyl)-2-oxoethyl]-4-hydroxy-pyran-2-one

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taurochenodeoxycholic acid

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9,10-dihydroxystearic acid

4,7-dioxooctanoic acid

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(2S,6R)-10-formyltetrahydrofolic acid

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2-sulfomethyl-L-thioproline

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(4r,5s,6s,7r)-4,7-Dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-one

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gamma-glutamyl-beta-cyanoalanine

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1,3-benzenedisulfonic acid

2-oxobut-3-enoic acid

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(S)-2-hydroxystearic acid

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1-arachidonoyl-sn-glycerol 3-phosphate

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3-[7,12,18-Tris(2-carboxyethyl)-3,8,13,17-tetrakis(carboxymethyl)-21,23-dihydroporphyrin-2-yl]propanoic acid

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N-acetylmuramoyl-L-alanine

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2-(Hydroxyamino)-3-methylbutanoic acid

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DL-methionine sulfone

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(5R/S)-biotin sulfoxide

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Cytosine deoxyribonucleoside

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Brunda Nijagal

2

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28 February 2020

Dong-Hyun Kim

3

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28 February 2020

Federico Rojas

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Keith Matthews

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Michael P. Barrett

6

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28 February 2020

author name string

Keith R Matthews

5

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17 August 2017

Michael P Barrett

6

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17 August 2017

language of work or name

English

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publication date

9 April 2013

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full work available at URL

28 February 2020

https://aac.asm.org/content/aac/57/6/2768.full.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1128/aac.00044-13?email=unpaywall_01@example.com

published in

Antimicrobial Agents and Chemotherapy

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28 February 2020

volume

57

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28 February 2020

page(s)

2768-2779

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28 February 2020

issue

6

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28 February 2020

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access restriction status

open access

1 reference

inferred from online access status

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Polyamine and pentamidine metabolism in African trypanosomes

29 September 2017

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Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense

29 September 2017

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Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes

29 September 2017

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Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitro

27 June 2018

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Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone).

27 June 2018

1 reference

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Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716122

Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine.

27 June 2018

1 reference

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Metabolomics profiling of cell culture media leading to the identification of riboflavin photosensitized degradation of tryptophan causing slow growth in cell culture.

4 September 2018

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Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

4 September 2018

1 reference

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Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites.

4 September 2018

1 reference

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Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards

4 September 2018

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MIRACLE: mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites

4 September 2018

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Further biochemical characterization of chronic Trypanosoma brucei gambiense-Microtus montanus infection

4 September 2018

1 reference

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Transport of methionine in Trypanosoma brucei brucei

4 December 2018

1 reference

12 December 2020

Cysteine is an essential growth factor for Trypanosoma brucei bloodstream forms

1 reference

12 December 2020

Nutritional requirements of Plasmodium falciparum in culture. III. Further observations on essential nutrients and antimetabolites

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12 December 2020

Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes

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12 December 2020

Identifiers

DOI

10.1128/AAC.00044-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23571546%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference