Gene therapy with drug resistance genes (Q36279821)

13 August 2017

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title

Gene therapy with drug resistance genes (English)

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13 August 2017

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Zaboikin M

1

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13 August 2017

Srinivasakumar N

series ordinal

2

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13 August 2017

Schuening F

series ordinal

3

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13 August 2017

1 April 2006

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13 August 2017

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13 August 2017

13

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13 August 2017

335-345

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13 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700912

13 August 2017

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cites work

Transfer of drug resistance genes in hematopoietic progenitors for chemoprotection: is it still an option?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Hematoprotection by Transfer of Drug-Resistance Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Protection and selection for gene therapy in the hematopoietic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Efficient transduction of human lymphocytes and CD34+ cells via human immunodeficiency virus-based gene transfer vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Gene therapy of X-linked severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Pharmacologically regulated cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Transfer and expression of the human multiple drug resistance gene into live mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

In vivo selection of retrovirally transduced hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

GST-pi gene-transduced hematopoietic progenitor cell transplantation overcomes the bone marrow toxicity of cyclophosphamide in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

The hematological effects of folate analogs: implications for using the dihydrofolate reductase gene for in vivo selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

P-glycoprotein: from genomics to mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

A bicistronic retroviral vector for protecting hematopoietic cells against antifolates and P-glycoprotein effluxed drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using bicistronic vectors with human multidrug resistance gene 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Feasibility of multidrug resistance (MDR-1) gene transfer in patients undergoing high-dose therapy and peripheral blood stem cell transplantation for lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

21 January 2018

Glutathione transferases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Human CD34+ cells do not express glutathione S-transferases alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Fibronectin fragment-facilitated retroviral transfer of the glutathione-S-transferase pi gene into CD34+ cells to protect them against alkylating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Coexpression of rat glutathione S-transferase A3 and human cytidine deaminase by a bicistronic retroviral vector confers in vitro resistance to nitrogen mustards and cytosine arabinoside in murine fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Transfer of the cytidine deaminase cDNA into hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Retrovirus-mediated gene transfer of the multidrug resistance-associated protein (MRP) cDNA protects cells from chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Leukemia case triggers tighter gene-therapy controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

7 January 2021

Gene therapy of severe combined immunodeficiencies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

7 January 2021

Class 1 and class 3 aldehyde dehydrogenase levels in the human tumor cell lines currently used by the National Cancer Institute to screen for potentially useful antitumor agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

7 January 2021

Coding region-specific destabilization of mRNA transcripts attenuates expression from retroviral vectors containing class 1 aldehyde dehydrogenase cDNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

7 January 2021

Murine leukemia induced by retroviral gene marking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700912

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700912

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Dimensions Publication ID

13 August 2017

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1 reference