The regulation of the B-cell gene expression programme by Pax5. (Q36999672)

17 August 2017

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title

The regulation of the B-cell gene expression programme by Pax5. (English)

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17 August 2017

Melissa L Holmes

1

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17 August 2017

Clare Pridans

series ordinal

2

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17 August 2017

Stephen L Nutt

series ordinal

3

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17 August 2017

13 November 2007

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Immunology & Cell Biology

17 August 2017

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17 August 2017

86

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17 August 2017

47-53

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17 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/sj.icb.7100134

17 August 2017

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cites work

The protean nature of cells in the B lymphocyte lineage

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The transcriptional regulation of B cell lineage commitment.

21 January 2018

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21 January 2018

The pre-B-cell receptor.

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Peripheral development of B cells in mouse and man.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Maintenance of serum antibody levels

21 January 2018

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B-cell memory: are subsets necessary?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Transcriptional control of early B cell development

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Contingent gene regulatory networks and B cell fate specification

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax5: the guardian of B cell identity and function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Early hematopoietic lineage restrictions directed by Ikaros.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Assembling a gene regulatory network for specification of the B cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Reversion of B cell commitment upon loss of Pax5 expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Structural studies of Ets-1/Pax5 complex formation on DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax-5 is essential for kappa sterile transcription during Ig kappa chain gene rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

BSAP can repress enhancer activity by targeting PU.1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

The balance between Pax5 and Id2 activities is the key to AID gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Lineage promiscuous expression of transcription factors in normal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Increasing Flt3L availability alters composition of a novel bone marrow lymphoid progenitor compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Loss of Pax5 promotes plasma cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Terminal differentiation of lymphocytes depends on Blimp-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

The transcriptional programme of antibody class switching involves the repressor Bach2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Pax‐5 is a key regulator of the B cell‐restricted expression of the CD23a isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

Context-dependent Pax-5 repression of a PU.1/NF-kappaB regulated reporter gene in B lineage cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

Loops, lineage, and leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

E2-2 regulates the expansion of pro-B cells and follicular versus marginal zone decisions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100134

7 January 2021

Identifiers

DOI

10.1038/SJ.ICB.7100134

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Dimensions Publication ID

17 August 2017

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