In vitro tests for predicting drug-drug interactions: the need for validated procedures (Q35060620)

6 August 2017

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title

In vitro tests for predicting drug-drug interactions: the need for validated procedures (English)

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6 August 2017

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Pierre Kremers

1

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6 August 2017

1 November 2002

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Basic and Clinical Pharmacology and Toxicology

6 August 2017

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6 August 2017

91

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6 August 2017

5

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6 August 2017

209-217

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Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples.

6 August 2017

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FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling.

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Application of in silico approaches to predicting drug--drug interactions

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

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Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver

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Role of drug metabolism in drug discovery and development

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Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

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Drug glucuronidation in clinical psychopharmacology

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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

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Carbamazepine: a 'blind' assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems

21 January 2018

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Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases

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Genotoxicity of 1,3- and 1,6-dinitropyrene: induction of micronuclei in a panel of mammalian test cell lines

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The effect of rofecoxib on the pharmacodynamics and pharmcokinetics of warfarin.

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Experimental and computational screening models for the prediction of intestinal drug absorption

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In vitro approaches to predicting drug interactions in vivo.

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Assessment of drug-drug interactions: concepts and approaches

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High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery

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Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery

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Development of predictive pharmacokinetic simulation models for drug discovery

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Bioanalytical method validation--a revisit with a decade of progress

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EUFEPS conference report. Optimising drug development: strategies to assess drug metabolism/transporter interaction potential - towards a consensus. European Federation of Pharmaceutical Sciences

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The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective

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Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

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Can drug-drug interactions be predicted from in vitro studies?

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7 January 2021

Clinical-pharmacological strategies to assess drug interaction potential during drug development

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Sense and nonsense in the prediction of drug-drug interactions

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Inhibition and induction of cytochrome P450 and the clinical implications

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Enzyme kinetics of cytochrome P450-mediated reactions

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Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

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Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

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Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

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Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12570028