Targeting the RNA-binding protein Sam68 as a treatment for cancer? (Q36967302)

17 August 2017

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title

Targeting the RNA-binding protein Sam68 as a treatment for cancer? (English)

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17 August 2017

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Kiven E Lukong

1

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PubMed ID

17927519

17 August 2017

Stéphane Richard

series ordinal

2

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PubMed ID

17927519

17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

3

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17 August 2017

539-544

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17 August 2017

5

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

17 August 2017

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Identification of novel genes coding for small expressed RNAs

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Noncoding RNAs and gene silencing

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

A unified theory of gene expression

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

RNA regulation and cancer development

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Post-transcriptional operons and regulons co-ordinating gene expression

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

RNA-binding proteins as regulators of gene expression.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

STAR, a gene family involved in signal transduction and activation of RNA.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Retardation of the G2-M phase progression on gene disruption of RNA binding protein Sam68 in the DT40 cell line

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Neoplastic transformation and tumorigenesis associated with sam68 protein deficiency in cultured murine fibroblasts

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Sam68 exerts separable effects on cell cycle progression and apoptosis

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

A target for Src in mitosis.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The interplay between Src family kinases and receptor tyrosine kinases

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

c-Src and cooperating partners in human cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

pp60c-src activation in lung adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Src family tyrosine kinases and growth factor signaling

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Selected glimpses into the activation and function of Src kinase

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The interplay between Src and integrins in normal and tumor biology

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

21 January 2018

A renaissance for SRC

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Involvement of pp60c-src with two major signaling pathways in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Functional interaction between c-Src and its mitotic target, Sam 68

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

RET oncoproteins induce tyrosine phosphorylation changes of proteins involved in RNA metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Tyrosine kinase inhibitors in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Mechanisms of focal adhesion kinase regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Association between src-kinases and the polyoma virus oncogene middle T-antigen requires PP2A and a specific sequence motif

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Snapshot: genetic mouse models of cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Signal-dependent regulation of splicing via phosphorylation of Sam68

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

Herceptin (trastuzamab) in advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.5.539

21 January 2018

Identifiers

DOI

10.2217/14796694.3.5.539

1 reference

17 August 2017

1 reference

PubMed ID

17927519