Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice (Q36941168)

17 August 2017

Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice (English)

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17 August 2017

1

Barbara Sennino

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17 August 2017

Toshina Ishiguro-Oonuma

2

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17 August 2017

Brian J Schriver

3

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17 August 2017

James G Christensen

4

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17 August 2017

Donald M McDonald

5

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17 August 2017

language of work or name

English

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publication date

10 April 2013

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17 August 2017

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17 August 2017

73

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17 August 2017

12

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17 August 2017

3692-3703

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describes a project that uses

17 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3686901/fullTextXML

inferred from PubMed Central ID database lookup

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Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors

29 September 2017

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Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors

29 September 2017

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29 September 2017

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Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence

29 September 2017

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Targeting MET in cancer: rationale and progress

29 September 2017

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Role of MetMAb (OA-5D5) in c-MET active lung malignancies

29 September 2017

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MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib

29 September 2017

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Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth

29 September 2017

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Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3

29 September 2017

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VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer

29 September 2017

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Lymphangiogenesis: Molecular mechanisms and future promise

29 September 2017

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Increased intratumoral lymphatic vessel density correlates with lymph node metastasis in early gastric carcinoma

29 September 2017

1 reference

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Crosstalk in Met receptor oncogenesis

29 September 2017

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Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer.

29 September 2017

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

29 September 2017

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

29 September 2017

1 reference

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VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

29 September 2017

1 reference

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Beyond VEGF: targeting tumor growth and angiogenesis via alternative mechanisms

29 September 2017

1 reference

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Markers for microscopic imaging of lymphangiogenesis and angiogenesis

29 September 2017

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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

29 September 2017

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Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

29 September 2017

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

29 September 2017

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A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities

29 September 2017

1 reference

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The MET receptor tyrosine kinase in invasion and metastasis

29 September 2017

1 reference

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c-Met is a potentially new therapeutic target for treatment of human melanoma

29 September 2017

1 reference

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Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration

29 September 2017

1 reference

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Targeting VEGF-A to treat cancer and age-related macular degeneration

29 September 2017

1 reference

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Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2.

29 September 2017

1 reference

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Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

29 September 2017

1 reference

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Hepatocyte growth factor promotes lymphatic vessel formation and function

29 September 2017

1 reference

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VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

29 September 2017

1 reference

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Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes

29 September 2017

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An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice

29 September 2017

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Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts

29 September 2017

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Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma

29 September 2017

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Expression of c-met is a strong independent prognostic factor in breast carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Prognostic significance of c-Met expression in glioblastomas

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Anatomy and nomenclature of murine lymph nodes: Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3686901

c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion

4 December 2018

1 reference

12 December 2020

Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis

1 reference

12 December 2020

Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension

1 reference

12 December 2020

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action

1 reference

12 December 2020

Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases

1 reference

12 December 2020

Halting angiogenesis suppresses carcinoma cell invasion

1 reference

12 December 2020

Cabozantinib approved for advanced medullary thyroid cancer

1 reference

12 December 2020

10.1158/0008-5472.CAN-12-2160

Identifiers

DOI

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17 August 2017

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17 August 2017

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