Toll-like receptors in systemic autoimmune disease (Q34576448)

3 August 2017

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title

Toll-like receptors in systemic autoimmune disease (English)

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autoimmune connective tissue disorder

3 August 2017

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inferred from title

author name string

Ann Marshak-Rothstein

series ordinal

1

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3 August 2017

1 November 2006

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Nature Reviews Immunology

3 August 2017

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3 August 2017

6

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3 August 2017

823-835

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3 August 2017

11

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Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

3 August 2017

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Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

31 March 2020

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Death, autoantigen modifications, and tolerance

31 March 2020

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The autoantibody repertoire: searching for order

31 March 2020

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Innate immune recognition: mechanisms and pathways

31 March 2020

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Endogenous ligands of Toll-like receptors

31 March 2020

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Type I interferons (alpha/beta) in immunity and autoimmunity

31 March 2020

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Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon

31 March 2020

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Possible induction of systemic lupus erythematosus by interferon-α treatment in a patient with a malignant carcinoid tumour

31 March 2020

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Induction of clinical autoimmune disease by therapeutic interferon-alpha

31 March 2020

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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

31 March 2020

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Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

31 March 2020

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Autoimmunity through cytokine-induced dendritic cell activation

31 March 2020

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A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus

31 March 2020

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Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells

31 March 2020

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An etiopathogenic role for the type I IFN system in SLE.

31 March 2020

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Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

31 March 2020

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Role of B-cell and Fc receptors in the selection of T-cell epitopes

31 March 2020

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Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG

31 March 2020

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

31 March 2020

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CpG motifs in bacterial DNA trigger direct B-cell activation

31 March 2020

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A Toll-like receptor recognizes bacterial DNA

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

31 March 2020

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Recognition of single-stranded RNA viruses by Toll-like receptor 7

31 March 2020

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

31 March 2020

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Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

31 March 2020

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Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

31 March 2020

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

31 March 2020

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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

31 March 2020

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

31 March 2020

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Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.

31 March 2020

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U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

31 March 2020

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Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

31 March 2020

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Predominant autoantibody production by early human B cell precursors

31 March 2020

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

31 March 2020

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Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

31 March 2020

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Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry

31 March 2020

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Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation

31 March 2020

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Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

31 March 2020

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Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice

31 March 2020

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31 March 2020

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

31 March 2020

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

31 March 2020

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Activation of autoreactive B cells by CpG dsDNA

31 March 2020

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The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.

31 March 2020

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Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation

31 March 2020

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

31 March 2020

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Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis

31 March 2020

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8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus

31 March 2020

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Immunogenicity of DNA Damaged by Reactive Oxygen Species—Implications for Anti-DNA Antibodies in Lupus

31 March 2020

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

31 March 2020

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Mechanism of photosensitivity in systemic lupus erythematosus patients

31 March 2020

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Generation of novel covalent RNA-protein complexes in cells by ultraviolet B irradiation: implications for autoimmunity

31 March 2020

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Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution

31 March 2020

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Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

31 March 2020

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Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

31 March 2020

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Toll-like receptor 9 signaling protects against murine lupus.

31 March 2020

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Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE

31 March 2020

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Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus

31 March 2020

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TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

31 March 2020

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T-bet regulates IgG class switching and pathogenic autoantibody production

31 March 2020

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Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice

31 March 2020

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Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

31 March 2020

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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

31 March 2020

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Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice

31 March 2020

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Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.

31 March 2020

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Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus.

31 March 2020

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Lupus erythematosus treated with a combination of quinacrine, hydroxychloroquine and chloroquine

31 March 2020

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

31 March 2020

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CpG motifs: the active ingredient in bacterial extracts?

31 March 2020

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Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

31 March 2020

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Sequence requirements for oligodeoxyribonucleotide inhibitory activity

31 March 2020

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G-rich DNA suppresses systemic lupus.

31 March 2020

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Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

31 March 2020

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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

31 March 2020

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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

31 March 2020

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Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

31 March 2020

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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

31 March 2020

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Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88

31 March 2020

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Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis

31 March 2020

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Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

31 March 2020

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TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease

31 March 2020

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Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease

31 March 2020

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Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

31 March 2020

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Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

31 March 2020

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Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-like receptor 4 by bacterial fimbria-dependent invasion

31 March 2020

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Toll-like Receptor 4 Polymorphisms and Atherogenesis

31 March 2020

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Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling

31 March 2020

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Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

31 March 2020

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Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).

31 March 2020

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Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

31 March 2020

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Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction.

31 March 2020

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Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice.

31 March 2020

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Regulation of lung injury and repair by Toll-like receptors and hyaluronan

31 March 2020

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CpG motifs in bacterial DNA and their immune effects

31 March 2020

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Differential signaling by CpG DNA in DCs and B cells: not just TLR9

31 March 2020

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Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

31 March 2020

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An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

31 March 2020

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Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

31 March 2020

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Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

31 March 2020

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

31 March 2020

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Hyaluronan fragments stimulate endothelial recognition of injury through TLR4.

31 March 2020

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The extra domain A of fibronectin activates Toll-like receptor 4.

31 March 2020

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Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells

31 March 2020

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Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4

31 March 2020

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Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

31 March 2020

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Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis

31 March 2020

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RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3.

31 March 2020

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31 March 2020

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31 March 2020

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A toll-like receptor that prevents infection by uropathogenic bacteria

31 March 2020

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TLR11 activation of dendritic cells by a protozoan profilin-like protein.

31 March 2020

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Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology

31 March 2020

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12 December 2020

Heat shock proteins as ligands of toll-like receptors.

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12 December 2020

DNA and RNA autoantigens as autoadjuvants

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12 December 2020

An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation

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12 December 2020

TLR7: A new sensor of viral infection

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12 December 2020

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.

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12 December 2020

Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds.

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12 December 2020

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity

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12 December 2020

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12 December 2020

A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis

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12 December 2020

Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content

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12 December 2020

High prevalence of immunoglobulin A antibody against Epstein-Barr virus capsid antigen in adult patients with lupus with disease flare: case control studies.

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12 December 2020

Mitogenicity of DNA from different organisms for murine B cells.

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12 December 2020

CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.

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12 December 2020

Identifiers

DOI

10.1038/NRI1957

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3 August 2017

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PubMed ID

17063184