Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia (Q36881957)

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scientific article published on 9 May 2016

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English	Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia	scientific article published on 9 May 2016

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4 April 2020

Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia (English)

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4 April 2020

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Hothri Ananyambica Moka

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David A Irvine

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Bin Zhang

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Anuradha Tarafdar

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Heather Morrison

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Victoria L Campbell

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Yinwei Ho

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Colin Nixon

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Paul W Manley

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Helen Wheadon

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Tessa L Holyoake

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Ravi Bhatia

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Mhairi Copland

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9 May 2016

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Scientific Reports

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25476

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Creative Commons Attribution 4.0 International

9 May 2016

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Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

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27 June 2018

Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation

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27 June 2018

PTCH1 expression at diagnosis predicts imatinib failure in chronic myeloid leukaemia patients in chronic phase.

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4 September 2018

Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia

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4 September 2018

Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR.

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4 September 2018

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

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Chronic myeloid leukaemia

1 reference

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12 December 2020

based on heuristic

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Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

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https://pubmed.ncbi.nlm.nih.gov/27157927

12 December 2020

based on heuristic

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High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations

1 reference

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12 December 2020

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Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression

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12 December 2020

based on heuristic

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Identifiers

10.1038/SREP25476

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4 April 2020

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4 April 2020

1 reference

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4 April 2020

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