Beta-catenin/LEF-1 signalling in breast cancer--central players activated by a plethora of inputs (Q36857760)

16 August 2017

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title

Beta-catenin/LEF-1 signalling in breast cancer--central players activated by a plethora of inputs (English)

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16 August 2017

Christoph A Gebeshuber

series ordinal

1

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PubMed ID

17587808

16 August 2017

Stefan Sladecek

series ordinal

2

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PubMed ID

17587808

16 August 2017

Stefan Grunert

series ordinal

3

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16 August 2017

1 January 2007

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16 August 2017

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16 August 2017

185

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16 August 2017

51-60

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16 August 2017

1-3

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Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

16 August 2017

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Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

21 January 2018

1 reference

The multifunctional role of transforming growth factor (TGF)-beta s on mammary epithelial cell biology

21 January 2018

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Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

21 January 2018

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An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

21 January 2018

1 reference

Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

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beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer

21 January 2018

1 reference

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

21 January 2018

1 reference

Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

21 January 2018

1 reference

Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

21 January 2018

1 reference

Wnt proteins in mammary development and cancer

21 January 2018

1 reference

A paracrine role for the epithelial progesterone receptor in mammary gland development

21 January 2018

1 reference

Wnt signaling in breast cancer: have we come full circle?

21 January 2018

1 reference

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

21 January 2018

1 reference

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.

21 January 2018

1 reference

Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a

21 January 2018

1 reference

Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.

21 January 2018

1 reference

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta

21 January 2018

1 reference

TGF-beta induces novel Lef-1 splice variants through a Smad-independent signaling pathway.

21 January 2018

1 reference

Synergistic effects of Vg1 and Wnt signals in the specification of dorsal mesoderm and endoderm.

21 January 2018

1 reference

Role of transforming growth factor-beta signaling in cancer

21 January 2018

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TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

1 reference

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

21 January 2018

1 reference

Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer

21 January 2018

1 reference

Control of neural crest cell fate by the Wnt signalling pathway.

21 January 2018

1 reference

Targeting the TGF beta signaling network in human neoplasia

21 January 2018

1 reference

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

21 January 2018

1 reference

Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity

21 January 2018

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beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.

21 January 2018

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Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription

21 January 2018

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Wnt-3A enhances bone morphogenetic protein-2-mediated chondrogenesis of murine C3H10T1/2 mesenchymal cells

21 January 2018

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Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling

21 January 2018

1 reference

Mammalian Groucho homologs: redundancy or specificity?

21 January 2018

1 reference

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

21 January 2018

1 reference

Beta-catenin and Tcfs in mammary development and cancer

21 January 2018

1 reference

Identification of c-MYC as a target of the APC pathway

21 January 2018

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Signaling pathways in mammary gland development.

21 January 2018

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The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing

21 January 2018

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Wnt signaling and breast cancer

21 January 2018

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Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma.

21 January 2018

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Nuclear localization of beta-catenin by interaction with transcription factor LEF-1

21 January 2018

1 reference

Requirement for beta-catenin in anterior-posterior axis formation in mice

21 January 2018

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Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development

21 January 2018

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TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

21 January 2018

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Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells

21 January 2018

1 reference

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

21 January 2018

1 reference

Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT.

21 January 2018

1 reference

The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3.

21 January 2018

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Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse

21 January 2018

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Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

21 January 2018

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Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2

21 January 2018

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Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

21 January 2018

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Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse

21 January 2018

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Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells

21 January 2018

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The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

21 January 2018

1 reference

A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells.

21 January 2018

1 reference

The Wnt signaling pathway in development and disease

21 January 2018

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Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

21 January 2018

1 reference

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin

21 January 2018

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Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition

21 January 2018

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Wnt-cadherin connections in normal and neoplastic mammary epithelium.

21 January 2018

1 reference

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways

21 January 2018

1 reference

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

21 January 2018

1 reference

WNT and beta-catenin signalling: diseases and therapies

21 January 2018

1 reference

TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

21 January 2018

1 reference

Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

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Head in the WNT: the molecular nature of Spemann's head organizer

21 January 2018

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Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

21 January 2018

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

21 January 2018

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Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

21 January 2018

1 reference

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

21 January 2018

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Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

21 January 2018

1 reference

Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells

21 January 2018

1 reference

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation

21 January 2018

1 reference

The oncogenic activation of beta-catenin

21 January 2018

1 reference

Wnt signalling in stem cells and cancer

21 January 2018

1 reference

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

21 January 2018

1 reference

Gastrula organiser and embryonic patterning in the mouse

21 January 2018

1 reference

Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

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Inhibition of beta-catenin-mediated transactivation by cadherin derivatives

21 January 2018

1 reference

Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling.

21 January 2018

1 reference

Dynamic expression of Lef/Tcf family members and beta-catenin during chick gastrulation, neurulation, and early limb development.

21 January 2018

1 reference

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

21 January 2018

1 reference

Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia

21 January 2018

1 reference

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

21 January 2018

1 reference

Wnt signaling and mammary tumorigenesis

21 January 2018

1 reference

Tcf/Lef transcription factors during T-cell development: unique and overlapping functions

21 January 2018

1 reference

Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.

21 January 2018

1 reference

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta

21 January 2018

1 reference

New insights into TGF-beta-Smad signalling

21 January 2018

1 reference

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

21 January 2018

1 reference

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

21 January 2018

1 reference

Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas

21 January 2018

1 reference

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice

21 January 2018

1 reference

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

21 January 2018

1 reference

TGF-beta signaling in mammary gland development and tumorigenesis.

21 January 2018

1 reference

TGF-beta signaling: positive and negative effects on tumorigenesis

21 January 2018

1 reference

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

21 January 2018

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Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

21 January 2018

1 reference

Lymphoid enhancer factor/T cell factor expression in colorectal cancer

21 January 2018

1 reference

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

21 January 2018

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A transcriptional response to Wnt protein in human embryonic carcinoma cells

21 January 2018

1 reference

Mechanisms of Wnt signaling in development

21 January 2018

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Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate

21 January 2018

1 reference

Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.

21 January 2018

1 reference

An HMG-box-containing T-cell factor required for thymocyte differentiation.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000101303

1 reference

16 August 2017

1 reference

PubMed ID

17587808