The oncogenic activation of beta-catenin (Q33540073)

27 July 2017

title

The oncogenic activation of beta-catenin (English)

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27 July 2017

Polakis P

1

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27 July 2017

publication date

1 February 1999

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Current Opinion in Genetics & Development

27 July 2017

published in

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27 July 2017

volume

9

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27 July 2017

issue

1

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27 July 2017

page(s)

15-21

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publication type of scholarly work

27 July 2017

review article

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Cell adhesion and signal transduction: the Armadillo connection

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Signal transduction of beta-catenin

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Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus

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Uncoupling cadherin-based adhesion from wingless signalling in Drosophila

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An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling

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Association of the APC gene product with beta-catenin

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Association of the APC tumor suppressor protein with catenins

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

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Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

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Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein

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Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation

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A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo

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Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis

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Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis during Retinal Development

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NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion

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Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein

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7 January 2021

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes

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7 January 2021

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

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7 January 2021

Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma

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7 January 2021

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

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7 January 2021

A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas

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A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals

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7 January 2021

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer

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Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.

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The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling

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7 January 2021

SARPs: A family of secreted apoptosis-related proteins

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Activating Smoothened mutations in sporadic basal-cell carcinoma

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7 January 2021

Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer

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7 January 2021

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

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7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

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7 January 2021

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

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7 January 2021

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

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Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

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7 January 2021

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

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7 January 2021

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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7 January 2021

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

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7 January 2021

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor

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7 January 2021

beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex

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7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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7 January 2021

Functional interaction of beta-catenin with the transcription factor LEF-1

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7 January 2021

Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion

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7 January 2021

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

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7 January 2021

Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing

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7 January 2021

Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

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7 January 2021

Identification of c- MYC as a Target of the APC Pathway

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7 January 2021

10.1016/S0959-437X(99)80003-3

Identifiers

DOI

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27 July 2017

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