Apoptosis in the development of the immune system (Q36850158)

16 August 2017

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title

Apoptosis in the development of the immune system (English)

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16 August 2017

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Opferman JT

1

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16 August 2017

15 June 2007

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Cell Death & Differentiation

16 August 2017

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16 August 2017

15

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16 August 2017

2

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16 August 2017

234-242

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402182

16 August 2017

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cites work

Caspases: killer proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The central effectors of cell death in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Mitochondria and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The mitochondrial death/life regulator in apoptosis and necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Toxic proteins released from mitochondria in cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Life in the balance: how BH3-only proteins induce apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Apoptosis and T-cell repertoire selection in the thymus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The role of cytokine receptor signaling in lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Molecular determinants of TCR expression and selection.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Receptor editing in lymphocyte development and central tolerance.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Selection of the T cell repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

IL-7: a key regulator of B lymphopoiesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Role of interleukin-7 in bone and T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Mouse models of cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Normal thymocyte negative selection in TRAIL-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The action of Bax and bcl-2 on T cell selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Receptor editing in self-reactive bone marrow B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

APRIL-deficient mice have normal immune system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

A role for FADD in T cell activation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

T cell-specific FADD-deficient mice: FADD is required for early T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

An essential role for c-FLIP in the efficient development of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Positive selection of thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Bax deficiency partially corrects interleukin-7 receptor alpha deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Activation and accumulation of B cells in TACI-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Regulation of the T-independent humoral response by TACI

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402182

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402182

1 reference

PubMed ID

17571082

Dimensions Publication ID

16 August 2017

0 references

1 reference

PubMed ID

17571082