Microenvironmental regulation of biomacromolecular therapies (Q36836602)

16 August 2017

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title

Microenvironmental regulation of biomacromolecular therapies (English)

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16 August 2017

Hyun Joon Kong

1

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16 August 2017

David J Mooney

series ordinal

2

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16 August 2017

publication date

1 June 2007

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Nature Reviews Drug Discovery

16 August 2017

published in

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16 August 2017

volume

6

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16 August 2017

issue

6

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16 August 2017

page(s)

455-463

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Differential control of cellular gene expression by diffusible and non-diffusible EGF.

16 August 2017

cites work

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Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro

21 January 2018

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Mitosis enhances transgene expression of plasmid delivered by cationic liposomes

21 January 2018

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Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium

21 January 2018

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Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex

21 January 2018

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Growth factor-induced therapeutic angiogenesis in the heart: protein therapy

21 January 2018

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Angiogenic inhibitors: a new therapeutic strategy in oncology

31 March 2020

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The application of bone morphogenetic proteins to dental tissue engineering

31 March 2020

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Delivery of peptides and proteins through the blood-brain barrier

31 March 2020

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A peptide carrier for the delivery of biologically active proteins into mammalian cells.

31 March 2020

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Arterial gene transfer of naked DNA for therapeutic angiogenesis: early clinical results

31 March 2020

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Progress towards in vivo use of siRNAs

31 March 2020

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Antisense therapy for cancer

31 March 2020

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Advances in the production of human therapeutic proteins in yeasts and filamentous fungi

31 March 2020

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Antibodies and genetically engineered related molecules: production and purification.

31 March 2020

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Recombinant protein therapeutics--success rates, market trends and values to 2010.

31 March 2020

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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

31 March 2020

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31 March 2020

Myocardial gene therapy

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The hemophilias--from royal genes to gene therapy

31 March 2020

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Advances in malignant mesothelioma

31 March 2020

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Protein therapeutics: new applications for pharmacogenetics

31 March 2020

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Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

31 March 2020

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Design and development of polymers for gene delivery

31 March 2020

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In vivo protein transduction: delivery of a biologically active protein into the mouse

31 March 2020

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Artificial viruses: a nanotechnological approach to gene delivery

31 March 2020

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Strategies for targeting protein therapeutics to selected tissues and cells

31 March 2020

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Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.

31 March 2020

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Synthetic DNA delivery systems

31 March 2020

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Current status of polymeric gene delivery systems

31 March 2020

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Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering

31 March 2020

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Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.

31 March 2020

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Polymeric growth factor delivery strategies for tissue engineering

31 March 2020

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Improving protein therapeutics with sustained-release formulations

31 March 2020

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Tumor metastasis: mechanistic insights and clinical challenges

31 March 2020

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Optimising non-viral gene delivery in a tumour spheroid model

31 March 2020

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

31 March 2020

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Convective flow increases lipoplex delivery rate to in vitro cellular monolayers.

31 March 2020

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Engineering cellular microenvironments to improve cell-based drug testing

31 March 2020

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Tensional homeostasis and the malignant phenotype

31 March 2020

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Capturing complex 3D tissue physiology in vitro

31 March 2020

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Tissue cells feel and respond to the stiffness of their substrate

31 March 2020

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Fibronectin requirement in branching morphogenesis.

31 March 2020

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Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

31 March 2020

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31 March 2020

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How does extracellular matrix control capillary morphogenesis?

31 March 2020

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Mechanobiology and diseases of mechanotransduction

31 March 2020

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Nutrition of the intervertebral disc

31 March 2020

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Fibrogenic cytokines and connective tissue production

31 March 2020

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Chemokines activate natural killer cells through heterotrimeric G-proteins: implications for the treatment of AIDS and cancer.

31 March 2020

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Impediments to wound healing

31 March 2020

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Extracellular matrix in bone marrow can mediate drug resistance in myeloma

31 March 2020

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Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche

31 March 2020

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Osteoblastic cells regulate the haematopoietic stem cell niche

31 March 2020

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Improving delivery of antineoplastic agents with anti-vascular endothelial growth factor therapy

31 March 2020

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Polymeric system for dual growth factor delivery

31 March 2020

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The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland

31 March 2020

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Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase.

31 March 2020

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Proliferation of mouse mammary epithelial cells in vitro: interactions among epidermal growth factor, insulin-like growth factor I, ovarian hormones, and extracellular matrix proteins

31 March 2020

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Spatial Confinement of Neurite Regrowth from Dorsal Root Ganglia within Nonporous Microconduits

31 March 2020

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Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration

31 March 2020

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Nanocomposite containing bioactive peptides promote endothelialisation by circulating progenitor cells: an in vitro evaluation

31 March 2020

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The response of VEGF-stimulated endothelial cells to angiostatic molecules is substrate-dependent

31 March 2020

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Distinct patterns of microvascular endothelial cell morphology are determined by extracellular matrix composition.

31 March 2020

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Geometric control of cell life and death

31 March 2020

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Nanoscale Adhesion Ligand Organization Regulates Osteoblast Proliferation and Differentiation

31 March 2020

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FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness

31 March 2020

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Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity.

31 March 2020

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Low molecular weight fucoidan and heparin enhance the basic fibroblast growth factor-induced tube formation of endothelial cells through heparan sulfate-dependent alpha6 overexpression.

31 March 2020

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Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity

31 March 2020

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The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.

31 March 2020

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

31 March 2020

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Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

31 March 2020

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Angiopoietin-1 induces sprouting angiogenesis in vitro

31 March 2020

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beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

31 March 2020

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Distinctive alterations of invasiveness, drug resistance and cell-cell organization in 3D-cultures of MCF-7, a human breast cancer cell line, and its multidrug resistant variant

31 March 2020

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Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology

31 March 2020

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Drug penetration in solid tumours

31 March 2020

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Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival

31 March 2020

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Vascular remodeling and clinical resistance to antiangiogenic cancer therapy.

31 March 2020

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Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization

31 March 2020

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Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials.

31 March 2020

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Protein-based signaling systems in tissue engineering

31 March 2020

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Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices.

31 March 2020

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Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth.

31 March 2020

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Repair of bone defects using synthetic mimetics of collagenous extracellular matrices

31 March 2020

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Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering

31 March 2020

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Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration.

31 March 2020

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Synergistic effect of keratinocyte transplantation and epidermal growth factor delivery on epidermal regeneration.

31 March 2020

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Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction.

31 March 2020

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Enhancement of the osteogenic efficacy of osteoblast transplantation by the sustained delivery of basic fibroblast growth factor.

31 March 2020

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Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells.

31 March 2020

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Enzyme-catalysed assembly of DNA hydrogel.

31 March 2020

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New approaches to nanofabrication: molding, printing, and other techniques

31 March 2020

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Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies

31 March 2020

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Recent advances in the application of gene therapy to human disease

31 March 2020

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF.

31 March 2020

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Tissue engineering by modulated gene delivery.

31 March 2020

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Ligand-targeted delivery of therapeutic siRNA.

31 March 2020

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RAF antisense oligonucleotide as a tumor radiosensitizer

31 March 2020

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Nonviral gene therapy: the promise of genes as pharmaceutical products

31 March 2020

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Inhibition of influenza virus production in virus-infected mice by RNA interference

31 March 2020

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Mechanisms of in Vivo DNA Electrotransfer: Respective Contributions of Cell Electropermeabilization and DNA Electrophoresis

31 March 2020

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Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer.

31 March 2020

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Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

31 March 2020

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Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression

31 March 2020

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Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion

31 March 2020

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Surface-mediated gene transfer from nanocomposites of controlled texture

31 March 2020

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Non-viral gene delivery regulated by stiffness of cell adhesion substrates.

31 March 2020

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Combination of 3D tissue engineered scaffold and non-viral gene carrier enhance in vitro DNA expression of mesenchymal stem cells.

31 March 2020

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Mechanical signal transduction in skeletal muscle growth and adaptation

31 March 2020

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Cell mechanics and mechanotransduction: pathways, probes, and physiology

31 March 2020

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Techniques for mechanical stimulation of cells in vitro: a review

31 March 2020

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Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells

31 March 2020

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Glucose-dependent insulin release from genetically engineered K cells

31 March 2020

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Recombinant vascular endothelial growth factor secreted from tissue-engineered bioartificial muscles promotes localized angiogenesis

31 March 2020

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Paracrine release of insulin-like growth factor 1 from a bioengineered tissue stimulates skeletal muscle growth in vitro.

31 March 2020

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Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems

31 March 2020

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Variability of naked DNA expression after direct local injection: the influence of the injection speed

31 March 2020

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Modifying the proliferative state of target cells to control DNA expression and identifying cell types transfected in vivo.

31 March 2020

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Augmenting the immunogenicity of DNA vaccines: role of plasmid-encoded Flt-3 ligand, as a molecular adjuvant in genetic vaccination

31 March 2020

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DNA delivery from polymer matrices for tissue engineering

31 March 2020

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Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration

31 March 2020

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Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration.

31 March 2020

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Bone regeneration by modified gene-activated matrix: effectiveness in segmental tibial defects in rats.

31 March 2020

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Continuous release of endostatin from microencapsulated engineered cells for tumor therapy

31 March 2020

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Regulating activation of transplanted cells controls tissue regeneration

31 March 2020

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Microscale technologies for tissue engineering and biology

31 March 2020

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Designing materials for biology and medicine

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2309

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16 August 2017

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