Design and development of polymers for gene delivery (Q36211579)

12 August 2017

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title

Design and development of polymers for gene delivery (English)

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12 August 2017

Daniel W Pack

1

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12 August 2017

Allan S Hoffman

series ordinal

2

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12 August 2017

Suzie Pun

series ordinal

3

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12 August 2017

Patrick S Stayton

series ordinal

4

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12 August 2017

1 July 2005

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Nature Reviews Drug Discovery

12 August 2017

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12 August 2017

4

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12 August 2017

7

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12 August 2017

581-593

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https://scigraph.springernature.com/pub.10.1038/nrd1775

12 August 2017

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Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

31 March 2020

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An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery

31 March 2020

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Cationic lipids used in gene transfer

31 March 2020

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Direct real-time molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I

31 March 2020

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DNA condensation by multivalent cations

31 March 2020

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Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells

31 March 2020

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DNA condensation for gene therapy as monitored by atomic force microscopy

31 March 2020

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Monitoring DNA/poly-L-lysine polyplex formation with time-resolved multiangle laser light scattering

31 March 2020

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DNA interpolyelectrolyte complexes as a tool for efficient cell transformation

31 March 2020

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Peptide-mediated gene delivery: influence of peptide structure on gene expression

31 March 2020

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Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes

31 March 2020

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Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

31 March 2020

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Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.

31 March 2020

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Mechanism of oligonucleotide release from cationic liposomes

31 March 2020

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Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery

31 March 2020

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PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

31 March 2020

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Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.

31 March 2020

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Steric Stabilization of poly-l-Lysine/DNA Complexes by the Covalent Attachment of Semitelechelic poly[N-(2-Hydroxypropyl)methacrylamide]

31 March 2020

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Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

31 March 2020

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Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA.

31 March 2020

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The Level of Hydrophobic Substitution and the Molecular Weight of Amphiphilic Poly-L-lysine-Based Polymers Strongly Affects Their Assembly into Polymeric Bilayer Vesicles

31 March 2020

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Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages

31 March 2020

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Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

31 March 2020

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PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

31 March 2020

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Glycosylated polylysine/DNA complexes: gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size

31 March 2020

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Receptor-mediated gene transfer into macrophages

31 March 2020

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In vitro gene delivery to hepatocytes with galactosylated polyethylenimine

31 March 2020

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Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes

31 March 2020

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Folate copolymer-mediated transfection of cultured cells

31 March 2020

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Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels

31 March 2020

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Transferrin-polycation conjugates as carriers for DNA uptake into cells

31 March 2020

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Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells

31 March 2020

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Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells

31 March 2020

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Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery

31 March 2020

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An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery

31 March 2020

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Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery

31 March 2020

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Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression

31 March 2020

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31 March 2020

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Evidence for the role of proteoglycans in cation-mediated gene transfer

31 March 2020

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Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/lactosylated polylysine complexes

31 March 2020

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Adenovirus enhancement of transferrin-polylysine-mediated gene delivery

31 March 2020

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Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes

31 March 2020

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Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes

31 March 2020

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High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

31 March 2020

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Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle

31 March 2020

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Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand.

31 March 2020

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Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

31 March 2020

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Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.

31 March 2020

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A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptide

31 March 2020

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Improved transfection using epithelial cell line-selected ligands and fusogenic peptides

31 March 2020

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Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells

31 March 2020

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Size-dependent DNA mobility in cytoplasm and nucleus

31 March 2020

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Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

31 March 2020

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Efficient active transport of gene nanocarriers to the cell nucleus

31 March 2020

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Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells

31 March 2020

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Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

31 March 2020

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Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence

31 March 2020

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Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines.

31 March 2020

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DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA

31 March 2020

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A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA.

31 March 2020

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Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin alpha.

31 March 2020

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Factors influencing the ability of nuclear localization sequence peptides to enhance nonviral gene delivery

31 March 2020

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The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes

31 March 2020

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Polylysine-based transfection systems utilizing receptor-mediated delivery

31 March 2020

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Receptor-mediated transport of DNA into eukaryotic cells

31 March 2020

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Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

31 March 2020

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Targeted gene delivery with a low molecular weight glycopeptide carrier

31 March 2020

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Anti-JL1 antibody-conjugated poly (L-lysine) for targeted gene delivery to leukemia T cells

31 March 2020

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

31 March 2020

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Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells

31 March 2020

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Tumor targeting with surface-shielded ligand--polycation DNA complexes.

31 March 2020

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Targeted transfer of polyethylenimine-avidin-DNA bioconjugates to hematopoietic cells using biotinylated monoclonal antibodies

31 March 2020

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A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine

31 March 2020

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Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system

31 March 2020

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Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

31 March 2020

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Polyethylenimine-based intravenous delivery of transgenes to mouse lung.

31 March 2020

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Polyethylenimine shows properties of interest for cystic fibrosis gene therapy

31 March 2020

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In vivo delivery to tumors of DNA complexed with linear polyethylenimine.

31 March 2020

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Partial acetylation of polyethylenimine enhances in vitro gene delivery.

31 March 2020

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Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

31 March 2020

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Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter

31 March 2020

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Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

31 March 2020

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Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter

31 March 2020

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In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers

31 March 2020

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Highly efficient suicide gene expression in hepatocellular carcinoma cells by epstein-barr virus-based plasmid vectors combined with polyamidoamine dendrimer

31 March 2020

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Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer

31 March 2020

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In vitro gene delivery by degraded polyamidoamine dendrimers

31 March 2020

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The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

31 March 2020

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Histidine containing peptides and polypeptides as nucleic acid vectors.

31 March 2020

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High transfection efficiency of poly(4-vinylimidazole) as a new gene carrier

31 March 2020

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Efficient gene transfer by histidylated polylysine/pDNA complexes

31 March 2020

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Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides

31 March 2020

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From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

31 March 2020

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Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin

31 March 2020

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Membrane Translocation of Charged Residues at the Tips of Hydrophobic Helices in the T Domain of Diphtheria Toxin†

31 March 2020

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Influence of endosome-destabilizing peptides on efficacy of anti-HIV immunotoxins

31 March 2020

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pH-dependent bilayer destabilization by an amphipathic peptide.

31 March 2020

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Membrane solubilization by a hydrophobic polyelectrolyte: surface activity and membrane binding

31 March 2020

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The design and synthesis of polymers for eukaryotic membrane disruption.

31 March 2020

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A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer

31 March 2020

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pH-sensitive polymers that enhance intracellular drug delivery in vivo

31 March 2020

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Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression.

31 March 2020

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Poly(propylacrylic acid)-mediated serum stabilization of cationic lipoplexes

31 March 2020

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Gene and other biological therapies for vascular diseases

31 March 2020

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A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs

31 March 2020

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Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs.

31 March 2020

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Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

31 March 2020

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New class of polymers for the delivery of macromolecular therapeutics

31 March 2020

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Effects of structure of beta-cyclodextrin-containing polymers on gene delivery

31 March 2020

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Structural effects of carbohydrate-containing polycations on gene delivery. 1. Carbohydrate size and its distance from charge centers

31 March 2020

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Structural effects of carbohydrate-containing polycations on gene delivery. 2. Charge center type

31 March 2020

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Structural effects of carbohydrate-containing polycations on gene delivery. 3. Cyclodextrin type and functionalization

31 March 2020

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Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers

31 March 2020

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Cyclodextrin-based pharmaceutics: past, present and future

31 March 2020

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Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with alpha-cyclodextrin

31 March 2020

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In vitro and in vivo gene transfer by an optimized alpha-cyclodextrin conjugate with polyamidoamine dendrimer

31 March 2020

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Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins

31 March 2020

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Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery.

31 March 2020

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Cyclodextrin-modified polyethylenimine polymers for gene delivery

31 March 2020

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Development of a nonviral gene delivery vehicle for systemic application

31 March 2020

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Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery

31 March 2020

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Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

31 March 2020

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Cationic hyperbranched poly(amino ester): a novel class of DNA condensing molecule with cationic surface, biodegradable three-dimensional structure, and tertiary amine groups in the interior.

31 March 2020

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Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice

31 March 2020

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Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA

31 March 2020

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pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the

31 March 2020

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Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library.

31 March 2020

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Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines

31 March 2020

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A polymer library approach to suicide gene therapy for cancer

31 March 2020

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A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.

31 March 2020

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Poly[Lys-(AEDTP)]: a cationic polymer that allows dissociation of pDNA/cationic polymer complexes in a reductive medium and enhances polyfection

31 March 2020

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Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine

31 March 2020

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Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

31 March 2020

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The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit

31 March 2020

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COCI

https://opencitations.net/index/coci/api/v1/citations/10.2533/CHIMIA.1997.34

8 July 2023

Identifiers

DOI

10.1038/NRD1775

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12 August 2017

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