Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. (Q36831553)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27044097%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages (English)

1 reference

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31 March 2020

1 reference

3

1 reference

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31 March 2020

Christian T Farrar

4

1 reference

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31 March 2020

Koen A Marijt

5

1 reference

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31 March 2020

Giorgio Seano

9

1 reference

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31 March 2020

Matija Snuderl

13

1 reference

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31 March 2020

23

Rakesh K Jain

1 reference

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31 March 2020

10

Keehoon Jung

1 reference

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31 March 2020

17

Alona Muzikansky

1 reference

31 March 2020

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12

Trupti Vardam

1 reference

31 March 2020

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11

Walid S Kamoun

1 reference

31 March 2020

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6

Jonas Kloepper

1 reference

31 March 2020

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22

Dai Fukumura

1 reference

31 March 2020

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Nathaniel D Kirkpatrick

2

object named as

Nathaniel D Kirkpatrick

1 reference

31 March 2020

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7

Meenal Datta

1 reference

31 March 2020

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20

Tracy T Batchelor

1 reference

31 March 2020

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Teresa E Peterson

1

1 reference

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31 March 2020

Zohreh Amoozgar

8

1 reference

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31 March 2020

Jermaine Goveia

14

1 reference

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31 March 2020

Sampurna Chatterjee

15

1 reference

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31 March 2020

Ana Batista

16

1 reference

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31 March 2020

Ching Ching Leow

18

1 reference

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31 March 2020

Lei Xu

19

1 reference

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31 March 2020

Dan G Duda

21

1 reference

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31 March 2020

language of work or name

English

0 references

publication date

4 April 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27044097%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

31 March 2020

published in

1 reference

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31 March 2020

volume

113

1 reference

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31 March 2020

issue

16

1 reference

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31 March 2020

page(s)

4470-4475

1 reference

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describes a project that uses

31 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4843449/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

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The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment

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29 September 2017

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29 September 2017

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Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.

29 September 2017

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Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy

29 September 2017

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

29 September 2017

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Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy

29 September 2017

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Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma

29 September 2017

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Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma

29 September 2017

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Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo

29 September 2017

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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

29 September 2017

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Accessories to the crime: functions of cells recruited to the tumor microenvironment

29 September 2017

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Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis

29 September 2017

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MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models

29 September 2017

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Antiangiogenic therapy for glioblastoma

29 September 2017

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Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.

29 September 2017

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Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy

29 September 2017

1 reference

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Molecular mechanisms and clinical applications of angiogenesis

29 September 2017

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

29 September 2017

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Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth

29 September 2017

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Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape

29 September 2017

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Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage

29 September 2017

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Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas

29 September 2017

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Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma

29 September 2017

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Macrophage diversity enhances tumor progression and metastasis

29 September 2017

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Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth

29 September 2017

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Macrophages, innate immunity and cancer: balance, tolerance, and diversity

29 September 2017

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Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

29 September 2017

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Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

29 September 2017

1 reference

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Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

29 September 2017

1 reference

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Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma

29 September 2017

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Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice

29 September 2017

1 reference

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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

29 September 2017

1 reference

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Angiopoietin-2: development of inhibitors for cancer therapy

29 September 2017

1 reference

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Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma

29 September 2017

1 reference

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Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

29 September 2017

1 reference

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Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis

29 September 2017

1 reference

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Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.

29 September 2017

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AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

29 September 2017

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer

29 September 2017

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Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

29 September 2017

1 reference

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Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis

29 September 2017

1 reference

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Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth

29 September 2017

1 reference

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

29 September 2017

1 reference

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Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

29 September 2017

1 reference

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Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.

29 September 2017

1 reference

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Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma

27 June 2018

1 reference

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Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4843449

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1525349113

Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27044097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27044097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1525349113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27044097%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27044097%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference