Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma (Q30661157)

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English	Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma	scientific article

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7 March 2020

Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma (English)

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7 March 2020

phase III clinical trial

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Paul Mulholland

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7 March 2020

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Martin J van den Bent

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Tom Mikkelsen

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Rakesh K Jain

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Tracy T Batchelor

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Tracy T Batchelor

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Bart Neyns

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Mario Campone

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Antje Wick

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Warren Mason

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Surasak Phuphanich

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Lynn S Ashby

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John Degroot

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Rao Gattamaneni

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Lawrence Cher

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Mark Rosenthal

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Franz Payer

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Juliane M Jürgensmeier

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A Gregory Sorensen

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John Xu

19

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Qi Liu

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12 August 2013

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7 March 2020

Journal of Clinical Oncology

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3212-3218

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26

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7 March 2020

Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021043

20 June 2018

Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma

1 reference

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20 June 2018

Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study

1 reference

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20 June 2018

FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme

1 reference

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20 June 2018

Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma

1 reference

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

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20 June 2018

Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma

1 reference

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Angiogenesis in brain tumours

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20 June 2018

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

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20 June 2018

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

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20 June 2018

AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer

1 reference

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20 June 2018

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

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Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

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Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials

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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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Chemotherapy of malignant glioma with CCNU alone and CCNU combined with vincristine sulfate and procarbazine hydrochloride.

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Nitrosourea chemotherapy for primary malignant gliomas.

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Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors.

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28 July 2018

Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group.

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25 November 2018

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

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25 November 2018

Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis.

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10.1200/JCO.2012.47.2464

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