Role of mitogen-activated protein kinase kinase kinases in signal integration (Q36819381)

16 August 2017

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title

Role of mitogen-activated protein kinase kinase kinases in signal integration (English)

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16 August 2017

Cuevas BD

1

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16 August 2017

Abell AN

series ordinal

2

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16 August 2017

Johnson GL

series ordinal

3

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16 August 2017

language of work or name

English

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publication date

1 May 2007

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16 August 2017

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16 August 2017

26

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16 August 2017

22

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16 August 2017

3159-3171

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210409

16 August 2017

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cites work

MEKK4 is an effector of the embryonic TRAF4 for JNK activation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Raf: a strategic target for therapeutic development against cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Structural basis for the interaction of TAK1 kinase with its activating protein TAB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Cortical migration defects in mice expressing A-RAF from the B-RAF locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

c-Mos and cyclin B/cdc2 connections during Xenopus oocyte maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Ser-3 is important for regulating Mos interaction with and stimulation of mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Expression of the Tpl2/Cot oncogene in human T-cell neoplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Regulation of Raf-1 by direct feedback phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7th Jan Waldenström Lecture. The biology of human cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mixed-lineage kinase control of JNK and p38 MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Identification and characterization of a novel MAP kinase kinase kinase, MLTK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

The ASK1-MAP kinase pathways in immune and stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Regulation of cell migration by the calcium-dependent protease calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

The TGF beta activated kinase TAK1 regulates vascular development in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Big mitogen-activated kinase regulates multiple members of the MEF2 protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mutational analysis of the ARAF gene in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Inhibition of microglial inflammation by the MLK inhibitor CEP-1347.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

What does Mos do in oocytes and somatic cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Essential function for the kinase TAK1 in innate and adaptive immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEF2C regulates c‐Jun but not TNF‐α gene expression in stimulated mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

The RAF proteins take centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Translational control of growth factor and proto-oncogene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Knockout of ERK5 causes multiple defects in placental and embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mekk3 is essential for early embryonic cardiovascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mos and the cell cycle: the molecular basis of the transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Mechanistic studies of the mitotic activation of Mos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

Integration of MAP kinase signal transduction pathways at the serum response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7 January 2021

Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7 January 2021

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7 January 2021

Kinase inhibitors in the treatment of renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7 January 2021

Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7 January 2021

Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages

1 reference

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7 January 2021

Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210409

7 January 2021

Overexpression of the Tpl-2/Cot oncogene in human breast cancer

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210409

1 reference

16 August 2017

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