The current state of knowledge on age, sex, and their interactions on clinical pharmacology (Q36818908)

16 August 2017

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title

The current state of knowledge on age, sex, and their interactions on clinical pharmacology (English)

1 reference

16 August 2017

1 reference

Schwartz JB

1

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PubMed ID

17495875

16 August 2017

language of work or name

English

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publication date

9 May 2007

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Clinical Pharmacology & Therapeutics

16 August 2017

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16 August 2017

82

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16 August 2017

87-96

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16 August 2017

1

1 reference

Estimating the Dosage of Ribavirin Aerosol According to Age and Other Variables

16 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: the symptomatic atrial fibrillation investigative research on dofetilide (SAFIRE-D) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

Variability of total phenytoin serum concentrations within elderly nursing home residents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

Sex is a major determinant of CYP3A4 expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

The age/gender interface in geriatric pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Sex differences in pharmacokinetics and pharmacodynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Gender-specific implications for cardiovascular medication use in the elderly optimizing therapy for older women

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The influence of sex on pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The influence of age and sex on the clearance of cytochrome P450 3A substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Altered pharmacokinetics in the elderly.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Neuroendocrinology of ageing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Aging biology and geriatric clinical pharmacology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Incidence and preventability of adverse drug events among older persons in the ambulatory setting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Adverse Drug Events in Ambulatory Care

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Risk factors for adverse drug events among nursing home residents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Patient risk factors for adverse drug events in hospitalized patients. ADE Prevention Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The incidence of adverse drug events in two large academic long-term care facilities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Incidence and predictors of bleeding events after fibrinolytic therapy with fibrin-specific agents: a comparison of TNK-tPA and rt-PA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

ASSENT-3: implications for future trial design and clinical practice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Verapamil disposition kinetics in chronic atrial fibrillation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Demographic considerations in tacrolimus pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Neoral use in the cardiac transplant recipient

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Disposition and first-pass metabolism of ethanol in humans: is it gastric or hepatic and does it depend on gender?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Transdermal delivery of narcotic analgesics: pH, anatomical, and subject influences on cutaneous permeability of fentanyl and sufentanil

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Prediction of creatinine clearance from serum creatinine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Prediction equations to estimate glomerular filtration rate: an update

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Assessing kidney function--measured and estimated glomerular filtration rate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Safety and effectiveness of dofetilide for conversion of atrial fibrillation and nesiritide for acute decompensation of heart failure: a report from the cardiovascular and renal advisory panel of the Food and Drug Administration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Cerivastatin and reports of fatal rhabdomyolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Sex Differences in Major Bleeding With Glycoprotein IIb/IIIa Inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Correlates of bleeding events among moderate- to high-risk patients undergoing percutaneous coronary intervention and treated with eptifibatide: observations from the PROTECT-TIMI-30 trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Cystatin C reference values and aging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Estimation of glomerular filtration rate in the elderly: a comparison of creatinine-based formulae with serum cystatin C.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft-Gault formula.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Clinical pharmacokinetics of mizolastine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Sex-dependent metabolism of xenobiotics.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Aging and the response to inhibition and induction of theophylline metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Application of population pharmacokinetics to the optimization of theophylline therapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Factors affecting theophylline clearances: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Differential pharmacokinetics of theophylline in elderly patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Bioequivalence revisited: influence of age and sex on CYP enzymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effect of Conjugated Equine Estrogens on Oxidative Metabolism in Middle-aged and Elderly Postmenopausal Women

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Olanzapine. Pharmacokinetic and pharmacodynamic profile.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Differential kinetics of phenytoin in elderly patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Phenytoin use in elderly nursing home residents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

An evaluation of antiepileptic drug therapy in nursing facilities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Pharmacological and clinical aspects of antiepileptic drug use in the elderly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effect of age on international normalized ratio at the time of major bleeding in patients treated with warfarin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effects of age and the CYP2D6∗10 allele on the plasma haloperidol concentration/dose ratio

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effect of age on in vitro triazolam biotransformation in male human liver microsomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Liver function and phase I drug metabolism in the elderly: a paradox

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Race and sex influence clearance of nifedipine: results of a population study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Population analyses of amlodipine in patients living in the community and patients living in nursing homes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Sex differences in CYP3A activity using intravenous and oral midazolam.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Erythromycin breath test results in elderly, very elderly, and frail elderly persons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder: a 6-month therapeutic drug monitoring study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Gender differences in the membrane transport of endogenous and exogenous compounds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Identification of functionally variant MDR1 alleles among European Americans and African Americans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

The biology of human sex differences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Representation of the elderly, women, and minorities in heart failure clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Drug metabolism and variability among patients in drug response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100226

7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100226

1 reference

16 August 2017

1 reference

PubMed ID

17495875