The influence of age and sex on the clearance of cytochrome P450 3A substrates (Q36000830)

11 August 2017

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title

The influence of age and sex on the clearance of cytochrome P450 3A substrates (English)

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11 August 2017

3

David J Greenblatt

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11 August 2017

2

Lisa L von Moltke

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11 August 2017

1

Monette M Cotreau

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11 August 2017

1 January 2005

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Clinical Pharmacokinetics

11 August 2017

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11 August 2017

44

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11 August 2017

1

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11 August 2017

33-60

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https://scigraph.springernature.com/pub.10.2165/00003088-200544010-00002

11 August 2017

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Faster clearance of sustained release verapamil in men versus women: continuing observations on sex-specific differences after oral administration of verapamil

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The genetic determinants of the CYP3A5 polymorphism

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Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

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Cocaine pharmacokinetics in men and in women during the follicular and luteal phases of the menstrual cycle

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Clarithromycin pharmacokinetics in healthy young and elderly volunteers

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Pharmacokinetics of buspirone in elderly subjects

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Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.

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Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.

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The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

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Influence of age and gender on the plasma profiles of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitory activity following multiple doses of lovastatin and simvastatin

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Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A.

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The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics

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12 December 2020

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

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12 December 2020

How important are gender differences in pharmacokinetics?

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12 December 2020

Drug interactions with grapefruit juice

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12 December 2020

Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil

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12 December 2020

Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains

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12 December 2020

Testosterone, body composition and aging

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Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.

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Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

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12 December 2020

The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis.

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Aging biology and geriatric clinical pharmacology

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Novel detection assay by PCR-RFLP and frequency of the CYP3A5 SNPs, CYP3A5*3 and *6, in a Japanese population

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12 December 2020

Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?

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12 December 2020

The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone

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12 December 2020

In vitro assessment of human cytochrome P450.

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12 December 2020

Structural basis of selective cytochrome P450 inhibition

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12 December 2020

The influence of age on the pharmacokinetics of verapamil.

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12 December 2020

Molecular and physical mechanisms of first-pass extraction

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12 December 2020

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

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12 December 2020

Sex is a major determinant of CYP3A4 expression in human liver

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12 December 2020

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Sex-dependent metabolism of xenobiotics.

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12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

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Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males

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12 December 2020

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

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Alprazolam pharmacokinetics in women on low-dose oral contraceptives

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Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult

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12 December 2020

Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking

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12 December 2020

Influence of age on toremifene pharmacokinetics

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12 December 2020

Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects.

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12 December 2020

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

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12 December 2020

Identification of an inducible form of cytochrome P-450 in human liver

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12 December 2020

Trazodone kinetics: effect of age, gender, and obesity

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12 December 2020

Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.

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12 December 2020

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

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12 December 2020

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?

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12 December 2020

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

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12 December 2020

Midazolam kinetics in women of two age groups

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12 December 2020

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

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12 December 2020

Reduced quinidine clearance in elderly persons

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12 December 2020

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

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12 December 2020

Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol

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12 December 2020

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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12 December 2020

Sensitivity to triazolam in the elderly.

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12 December 2020

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

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12 December 2020

Effect of age, gender, and obesity on midazolam kinetics.

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12 December 2020

Human cytochrome P450s: selectivity and measurement in vivo

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12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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12 December 2020

Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses

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12 December 2020

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

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12 December 2020

Oxidative metabolism of zolpidem by human liver cytochrome P450S

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12 December 2020

Influence of menstrual cycle and gender on alprazolam pharmacokinetics

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12 December 2020

Pharmacokinetic interaction between isradipine and lovastatin in normal, female and male volunteers

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12 December 2020

Age changes in body composition revealed by computed tomography

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12 December 2020

Alfentanil kinetics in the elderly

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12 December 2020

A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects

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12 December 2020

Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension

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12 December 2020

Influence of age on the pharmacokinetics of alfentanil. Gender dependence.

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12 December 2020

Effect of age on in vitro triazolam biotransformation in male human liver microsomes

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12 December 2020

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12 December 2020

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate

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12 December 2020

Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.

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12 December 2020

Age, Disease, and Changing Sex Hormone Levels in Middle-Aged Men: Results of the Massachusetts Male Aging Study*

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12 December 2020

Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions

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12 December 2020

Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects

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12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

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12 December 2020

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

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12 December 2020

Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone.

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12 December 2020

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

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12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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12 December 2020

In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes.

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12 December 2020

The effect of age upon liver volume and apparent liver blood flow in healthy man.

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12 December 2020

No evidence of a genetic polymorphism in the oxidative metabolism of midazolam.

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12 December 2020

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

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12 December 2020

Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation.

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12 December 2020

Total and functional hepatic blood flow decrease in parallel with ageing

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12 December 2020

Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics

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12 December 2020

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

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12 December 2020

Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction

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12 December 2020

Cytochrome P-450 3A4: regulation and role in drug metabolism

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12 December 2020

First-pass metabolism of midazolam by the human intestine.

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12 December 2020

Sequences of intestinal and hepatic cytochrome P450 3A4 cDNAs are identical

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12 December 2020

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

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12 December 2020

Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil.

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12 December 2020

Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of adinazolam and N-desmethyladinazolam after oral and intravenous dosing in healthy young and elderly volunteers

1 reference

12 December 2020

Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction.

1 reference

12 December 2020

Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans

1 reference

12 December 2020

STUDIES OF UREA EXCRETION. III: The Influence of Body Size on Urea Output

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12 December 2020

In vitro and in vivo drug interactions involving human CYP3A.

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12 December 2020

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

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12 December 2020

Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity

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12 December 2020

Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics.

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12 December 2020

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine

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12 December 2020

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

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12 December 2020

Age and nature of operation influence the pharmacokinetics of midazolam.

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12 December 2020

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

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12 December 2020

Grapefruit juice substantially increases plasma concentrations of buspirone

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12 December 2020

Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.

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12 December 2020

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

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12 December 2020

The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone

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12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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12 December 2020

Clearance approaches in pharmacology.

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12 December 2020

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions

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12 December 2020

Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes

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12 December 2020

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

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12 December 2020

Identification of a polymorphically expressed member of the human cytochrome P-450III family

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12 December 2020

Effect of age and gender on tirilazad pharmacokinetics in humans

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12 December 2020

The influence of aging on plasma sex hormones in men: the Telecom Study

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12 December 2020

The effects of age and liver disease on the disposition and elimination of diazepam in adult man

1 reference

12 December 2020

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

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12 December 2020

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

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12 December 2020

Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

1 reference

12 December 2020

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

1 reference

12 December 2020

Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.

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12 December 2020

Disposition of alprazolam in human volunteers. Differences between genders

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12 December 2020

The effect of hormone replacement therapy on CYP3A activity.

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12 December 2020

Drug therapy: drug disposition in old age.

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12 December 2020

Drug metabolism and drug interactions in the elderly

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12 December 2020

Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir

1 reference

12 December 2020

Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6.

1 reference

12 December 2020

Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression.

1 reference

12 December 2020

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

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12 December 2020

Drug interactions with grapefruit juice: an update

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12 December 2020

Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam.

1 reference

12 December 2020

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies

1 reference

12 December 2020

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1 reference

12 December 2020

Diazepam disposition determinants.

1 reference

12 December 2020

Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance

1 reference

12 December 2020

Pharmacokinetics and blood pressure effects of felodipine in elderly hypertensive patients. A comparison with young healthy subjects

1 reference

12 December 2020

New insights into the pharmacodynamic and pharmacokinetic properties of statins.

1 reference

12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

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12 December 2020

Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.

1 reference

12 December 2020

Androgen Secretion after Age 50 in Both Sexes

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12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

1 reference

12 December 2020

The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics.

1 reference

12 December 2020

A study of the effect of age and gender on the pharmacokinetics of nefazodone after single and multiple doses

1 reference

12 December 2020

Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs

1 reference

12 December 2020

Sex differences in pharmacokinetics and pharmacodynamics

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.

1 reference

12 December 2020

The effect of age on the pharmacokinetics and pharmacodynamics of midazolam.

1 reference

12 December 2020

Effect of subject age and gender on the pharmacokinetics of oral triazolam and temazepam

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12 December 2020

The influence of sex on pharmacokinetics

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12 December 2020

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1 reference

12 December 2020

Prolonged midazolam elimination half-life

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12 December 2020

Alprazolam kinetics in the elderly. Relation to antipyrine disposition

1 reference

12 December 2020

Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies.

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12 December 2020

Molecular genetics of the human cytochrome P450 monooxygenase superfamily

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes

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12 December 2020

Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans

1 reference

12 December 2020

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

12 December 2020

The influence of age on the pharmacokinetics of nimodipine.

1 reference

12 December 2020

Effects of sex on the pharmacokinetic and pharmacodynamic properties of quinidine

1 reference

12 December 2020

Lidocaine disposition--sex differences and effects of cimetidine.

1 reference

12 December 2020

Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone

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12 December 2020

Grapefruit juice-drug interactions

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12 December 2020

Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir.

1 reference

12 December 2020

A comparison of the disposition of single oral doses of amlodipine in young and elderly subjects

1 reference

12 December 2020

Increased baseline sway contributes to increased losses of balance in older people following triazolam

1 reference

12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

1 reference

12 December 2020

Effect of age and gender on pharmacokinetics of atorvastatin in humans.

1 reference

12 December 2020

Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines

1 reference

12 December 2020

In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.

1 reference

12 December 2020

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

1 reference

12 December 2020

Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences.

1 reference

12 December 2020

Effect of Gender and Menopausal Status on the Pharmacokinetics of Tirilazad Mesylate in Healthy Subjects

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12 December 2020

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

1 reference

12 December 2020

The effects of age and gender on the stereoselective pharmacokinetics of verapamil

1 reference

12 December 2020

Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.

1 reference

12 December 2020

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

1 reference

12 December 2020

The effect of age on the pharmacokinetics of ifosfamide

1 reference

12 December 2020

On the characteristics of actinomycin D resistance in L5178Y cells.

1 reference

12 December 2020

Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: cross-sectional differences in 60-year-old persons

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12 December 2020

Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors.

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12 December 2020

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

1 reference

12 December 2020

Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction

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12 December 2020

Aging alters verapamil elimination and dynamics: single dose and steady-state responses.

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12 December 2020

Aging effects on drug disposition and effect

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12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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12 December 2020

Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampin

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12 December 2020

Sex is a major determinant of CYP3A4 expression in human liver

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12 December 2020

10.2165/00003088-200544010-00002

Identifiers

DOI

1 reference

PubMed ID

15634031

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15634031