Structural principles of tau and the paired helical filaments of Alzheimer's disease (Q36817219)

16 August 2017

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title

Structural principles of tau and the paired helical filaments of Alzheimer's disease (English)

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16 August 2017

4

Eva-Maria Mandelkow

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Eckhard Mandelkow

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1

object named as

Eckhard Mandelkow

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16 August 2017

2

Martin von Bergen

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16 August 2017

Jacek Biernat

3

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16 August 2017

1 January 2007

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16 August 2017

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16 August 2017

17

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16 August 2017

1

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16 August 2017

83-90

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MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments

16 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Proteolysis of non-phosphorylated and phosphorylated tau by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau protein binds to microtubules through a flexible array of distributed weak sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Microtubule stabilization by assembly-promoting microtubule-associated proteins: a repeat performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Ligand-dependent inhibition and reversal of tau filament formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Primary structure of high molecular weight tau present in the peripheral nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Straight and paired helical filaments in Alzheimer disease have a common structural unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau pathology: a marker of neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

In vitro assembly of Alzheimer-like filaments. How a small cluster of charged residues in Tau and MAP2 controls filament morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: identification of hidden and cleaved tau epitopes and a new phosphorylation site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau protein function in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Regulation of tau isoform expression and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The formation of straight and twisted filaments from short tau peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau proteins: the molecular structure and mode of binding on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with x-ray structure and implications for motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Structure of core domain of fibril-forming PHF/Tau fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Global hairpin folding of tau in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Mammalian SAD kinases are required for neuronal polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Developmentally regulated expression of specific tau sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Characterization of paired helical filaments by scanning transmission electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The primary structure and heterogeneity of tau protein from mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Phosphorylation of tau by fyn: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Competition for microtubule-binding with dual expression of tau missense and splice isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

A decade of modeling Alzheimer's disease in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Evidence for two distinct binding sites for tau on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Template-assisted filament growth by parallel stacking of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Side chain-dependent stacking modulates tau filament structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Recent atomic models of amyloid fibril structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Non-motor microtubule-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

P70 S6 kinase mediates tau phosphorylation and synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau interaction with microtubules in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Surface-decoration of microtubules by human tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Single-molecule investigation of the interference between kinesin, tau and MAP2c

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Regions of tau implicated in the paired helical fragment core as defined by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Tau phosphorylation: physiological and pathological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Progress towards a molecular-level structural understanding of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

A protein factor essential for microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2007.00053.X

10.1111/J.1750-3639.2007.00053.X

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17493042