Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. (Q34132759)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163132%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

review article

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title

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163132%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163132%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

M L Garcia

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163132%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

publication date

1 February 2001

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Current Opinion in Cell Biology

3 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163132%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

13

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3 November 2019

page(s)

41-48

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3 November 2019

issue

1

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Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

3 November 2019

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Dynamic instability of microtubule growth

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Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions

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Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

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FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10

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Abnormal microtubule packing in processes of SF9 cells expressing the FTDP-17 V337M tau mutation

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Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

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Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

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A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration.

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The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian cases

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5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.

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Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.

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Determinants of 4-repeat tau expression. Coordination between enhancing and inhibitory splicing sequences for exon 10 inclusion

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease

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7 January 2021

10.1016/S0955-0674(00)00172-1

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163132%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

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