The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation (Q36783013)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013235%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation (English)

1 reference

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31 March 2020

3

1 reference

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31 March 2020

Ziv Porat

5

1 reference

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31 March 2020

Moshe Oren

13

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31 March 2020

1

Yael Aylon

1 reference

31 March 2020

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2

Anat Gershoni

1 reference

31 March 2020

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Inbal E Biton

4

1 reference

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31 March 2020

Anna P Koh

6

1 reference

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31 March 2020

Xiaochen Sun

7

1 reference

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31 March 2020

Youngmin Lee

8

1 reference

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31 March 2020

Maria-Isabel Fiel

9

1 reference

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31 March 2020

Yujin Hoshida

10

1 reference

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31 March 2020

Scott L Friedman

11

1 reference

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31 March 2020

Randy L Johnson

12

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31 March 2020

publication date

24 March 2016

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31 March 2020

1 reference

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31 March 2020

volume

30

1 reference

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31 March 2020

issue

7

1 reference

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31 March 2020

page(s)

786-797

1 reference

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Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer

31 March 2020

cites work

1 reference

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The emerging roles of YAP and TAZ in cancer

29 September 2017

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29 September 2017

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Hippo pathway activity influences liver cell fate

29 September 2017

1 reference

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Lats2 is critical for the pluripotency and proper differentiation of stem cells

29 September 2017

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Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

29 September 2017

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LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.

29 September 2017

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DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery

29 September 2017

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Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.

29 September 2017

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Expanding roles for SREBP in metabolism

29 September 2017

1 reference

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Ductular reactions in human liver: diversity at the interface

29 September 2017

1 reference

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Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

29 September 2017

1 reference

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Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis

29 September 2017

1 reference

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Role of YAP/TAZ in mechanotransduction

29 September 2017

1 reference

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Regulation of cholesterol and fatty acid synthesis

29 September 2017

1 reference

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

29 September 2017

1 reference

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The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

29 September 2017

1 reference

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LATS tumor suppressor: a new governor of cellular homeostasis

29 September 2017

1 reference

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Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

29 September 2017

1 reference

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Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

29 September 2017

1 reference

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Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

29 September 2017

1 reference

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p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.

29 September 2017

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Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

29 September 2017

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Senescence of activated stellate cells limits liver fibrosis

29 September 2017

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SREBPs: the crossroads of physiological and pathological lipid homeostasis

29 September 2017

1 reference

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

29 September 2017

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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

29 September 2017

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Increased lipogenesis in cancer cells: new players, novel targets.

29 September 2017

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

29 September 2017

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Apoptosis: a mechanism of acute and chronic liver injury

29 September 2017

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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

29 September 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

29 September 2017

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

29 September 2017

1 reference

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The origin and liver repopulating capacity of murine oval cells

29 September 2017

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p53 Activation in Adipocytes of Obese Mice

29 September 2017

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Monocyte-derived multinucleated giant cells and sarcoidosis

29 September 2017

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The role of hepatocytes and oval cells in liver regeneration and repopulation

29 September 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

29 September 2017

1 reference

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Hepatic fibrosis. Pathogenesis and principles of therapy

29 September 2017

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

29 September 2017

1 reference

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

29 September 2017

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Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

29 September 2017

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SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

29 September 2017

1 reference

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Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

29 September 2017

1 reference

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Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis

27 June 2018

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Metabolic control of YAP and TAZ by the mevalonate pathway.

27 June 2018

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Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis.

5 September 2018

1 reference

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Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population.

5 September 2018

1 reference

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Characterization of ductular hepatocytes in primary liver allograft failure

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27013235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A new role of p53 in regulating lipid metabolism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27013235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.274167.115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013235%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013235%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference