LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. (Q34393614)

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3 March 2020

title

LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction (English)

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3 March 2020

8

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author name string

Jiong Li

1

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3 March 2020

Xiaohong Chen

2

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3 March 2020

Xiangming Ding

3

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Yingduan Cheng

4

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3 March 2020

Bin Zhao

5

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3 March 2020

Zhi-Chun Lai

6

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3 March 2020

Khalid Al Hezaimi

7

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Kun-Liang Guan

9

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Cun-Yu Wang

10

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publication date

19 December 2013

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3 March 2020

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volume

5

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page(s)

1650-1663

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issue

6

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Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

3 March 2020

cites work

1 reference

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Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.

6 July 2018

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The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

6 July 2018

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A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth

6 July 2018

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6 July 2018

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The Hippo pathway regulates Wnt/beta-catenin signaling

6 July 2018

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6 July 2018

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Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

6 July 2018

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6 July 2018

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MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer.

6 July 2018

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Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

6 July 2018

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TEAD mediates YAP-dependent gene induction and growth control

6 July 2018

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Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

6 July 2018

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TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis

6 July 2018

1 reference

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Elucidation of a universal size-control mechanism in Drosophila and mammals

6 July 2018

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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

6 July 2018

1 reference

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Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo

6 July 2018

1 reference

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

6 July 2018

1 reference

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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

6 July 2018

1 reference

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

6 July 2018

1 reference

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LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

6 July 2018

1 reference

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The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897473

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897473

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897473

Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila

6 July 2018

1 reference

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Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis

6 July 2018

1 reference

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Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

6 July 2018

1 reference

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Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription

6 July 2018

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Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

6 July 2018

1 reference

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

6 July 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

6 July 2018

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

6 July 2018

1 reference

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Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase

6 July 2018

1 reference

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

6 July 2018

1 reference

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Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897473

The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897473

Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24360964

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2013.11.037

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3 March 2020

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3 March 2020

1 reference

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