The study of Golgi apparatus in Alzheimer's disease (Q36777475)

16 August 2017

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title

The study of Golgi apparatus in Alzheimer's disease (English)

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16 August 2017

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Zhiping Hu

1

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16 August 2017

Liuwang Zeng

2

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16 August 2017

Zhiling Huang

3

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16 August 2017

Jie Zhang

4

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16 August 2017

Ting Li

5

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16 August 2017

publication date

31 March 2007

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16 August 2017

published in

Neurochemical Research

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16 August 2017

volume

32

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16 August 2017

issue

8

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16 August 2017

page(s)

1265-1277

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https://scigraph.springernature.com/pub.10.1007/s11064-007-9302-4

16 August 2017

exact match

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cites work

Increased metabolic activity in nucleus basalis of Meynert neurons in elderly individuals with mild cognitive impairment as indicated by the size of the Golgi apparatus

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9302-4

ApoE epsilon4 genotype is accompanied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9302-4

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9302-4

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9302-4

Fragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9302-4

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

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12 December 2020

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

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12 December 2020

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

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12 December 2020

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

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12 December 2020

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

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12 December 2020

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

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12 December 2020

Significance of intracellular Abeta42 accumulation in Alzheimer's disease.

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12 December 2020

Changes in metabolic activity and estrogen receptors in the human medial mamillary nucleus: relation to sex, aging and Alzheimer's disease.

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12 December 2020

Therapeutic strategies for Alzheimer disease: focus on neuronal reactivation of metabolically impaired neurons

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12 December 2020

Early changes in neurons of the hippocampus and neocortex in transgenic rats expressing intracellular human a-beta.

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12 December 2020

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

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12 December 2020

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

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12 December 2020

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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12 December 2020

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

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12 December 2020

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome.

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12 December 2020

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

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12 December 2020

A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.

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12 December 2020

Sex differences in estrogen receptor alpha and beta expression in vasopressin neurons of the supraoptic nucleus in elderly and Alzheimer's disease patients: no relationship with cytoskeletal alterations.

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12 December 2020

Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat.

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12 December 2020

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

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12 December 2020

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells

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12 December 2020

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

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12 December 2020

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

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12 December 2020

2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex

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12 December 2020

Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling

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12 December 2020

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

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12 December 2020

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

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12 December 2020

Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

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12 December 2020

Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cells.

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12 December 2020

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

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12 December 2020

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

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12 December 2020

A non-amyloidogenic function of BACE-2 in the secretory pathway

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12 December 2020

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

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12 December 2020

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

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12 December 2020

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

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12 December 2020

Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation

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12 December 2020

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

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12 December 2020

Intracellular A-beta amyloid, a sign for worse things to come?

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12 December 2020

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Alzheimer beta-amyloid peptides: normal and abnormal localization

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12 December 2020

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

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12 December 2020

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

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12 December 2020

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

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12 December 2020

The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

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12 December 2020

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

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12 December 2020

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

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12 December 2020

BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

1 reference

12 December 2020

The over-expression of the wild type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line.

1 reference

12 December 2020

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

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12 December 2020

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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12 December 2020

Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components

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12 December 2020

Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.

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12 December 2020

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

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12 December 2020

Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.

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12 December 2020

Increased neuronal metabolic activity and estrogen receptors in the vertical limb of the diagonal band of Broca in Alzheimer's disease: relation to sex and aging.

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12 December 2020

Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.

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12 December 2020

Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.

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12 December 2020

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

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12 December 2020

Factors influencing the processing and function of the amyloid beta precursor protein--a potential therapeutic target in Alzheimer's disease?

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12 December 2020

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Expansion of the Golgi apparatus in rat cerebral cortex following intracerebroventricular injections of streptozotocin.

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12 December 2020

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation

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12 December 2020

Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death

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12 December 2020

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

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12 December 2020

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

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12 December 2020

Golgi disassembly in apoptosis: cause or effect?

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12 December 2020

Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly

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12 December 2020

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

1 reference

12 December 2020

Diminished neuronal metabolic activity in Alzheimer's disease. Review article

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12 December 2020

Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

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12 December 2020

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

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12 December 2020

Estrogen receptor alpha and its splice variants in the hippocampus in aging and Alzheimer's disease.

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12 December 2020

Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines

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12 December 2020

Alzheimer disease: presenilin springs a leak.

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12 December 2020

Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairment.

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12 December 2020

The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse

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12 December 2020

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

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12 December 2020

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

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12 December 2020

The Golgi apparatus at the cell centre

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12 December 2020

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

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12 December 2020

Estrogen receptors and metabolic activity in the human tuberomamillary nucleus: changes in relation to sex, aging and Alzheimer's disease

1 reference

12 December 2020

Mutant presenilin (A260V) affects Rab8 in PC12D cell

1 reference

12 December 2020

10.1007/S11064-007-9302-4

Identifiers

DOI

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16 August 2017

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