Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation (Q73572502)

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5 November 2019

title

Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation (English)

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5 November 2019

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S Sudoh

1

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5 November 2019

G Hua

2

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5 November 2019

Y Kawamura

3

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5 November 2019

K Maruyama

4

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5 November 2019

H Komano

5

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5 November 2019

K Yanagisawa

6

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5 November 2019

publication date

1 April 2000

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5 November 2019

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5 November 2019

volume

267

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5 November 2019

issue

7

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5 November 2019

page(s)

2036-2045

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Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

5 November 2019

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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21 January 2018

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21 January 2018

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

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Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid

21 January 2018

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Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

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10.1046/J.1432-1327.2000.01206.X

21 January 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10727943%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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