Strategies to reduce late-stage drug attrition due to mitochondrial toxicity (Q36748508)

16 August 2017

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title

Strategies to reduce late-stage drug attrition due to mitochondrial toxicity (English)

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16 August 2017

James A Dykens

1

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16 August 2017

Lisa D Marroquin

series ordinal

2

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16 August 2017

Yvonne Will

series ordinal

3

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16 August 2017

publication date

1 March 2007

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

16 August 2017

published in

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16 August 2017

volume

7

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16 August 2017

issue

2

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16 August 2017

page(s)

161-175

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The effect of peroxisome proliferators on mitochondrial bioenergetics.

16 August 2017

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Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

21 January 2018

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Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart

21 January 2018

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Mitochondrial targets of drug toxicity

21 January 2018

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Drug-induced mitochondrial toxicity

21 January 2018

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The nongenotoxic hepatocarcinogen Wy-14,643 is an uncoupler of oxidative phosphorylation in vivo

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Doxorubicin-induced cardiac mitochondrionopathy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones

21 January 2018

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Anti-HIV drugs and the mitochondria

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Direct, DNA pol-gamma-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergetics

21 January 2018

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Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.

21 January 2018

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Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

21 January 2018

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Mitochondria as a pharmacological target

21 January 2018

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Drug-associated mitochondrial toxicity and its detection

21 January 2018

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Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver

21 January 2018

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Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity

21 January 2018

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Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids

21 January 2018

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Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?

21 January 2018

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Mitochondrially-mediated toxicity of bile acids.

21 January 2018

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Involvement of mitochondrial inner membrane anion carriers in the uncoupling effect of fatty acids

21 January 2018

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The biochemistry and toxicity of atractyloside: a review.

21 January 2018

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The uncoupling agent 2,4-dinitrophenol improves mitochondrial homeostasis following striatal quinolinic acid injections

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Hepatotoxicity of antiretrovirals: incidence, mechanisms and management

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondrial damage by the "pro-oxidant" peroxisomal proliferator clofibrate

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs).

21 January 2018

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Toxicity of statins on rat skeletal muscle mitochondria

21 January 2018

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Mechanisms of troglitazone hepatotoxicity

21 January 2018

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Statins and myotoxicity: a therapeutic limitation

21 January 2018

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Simvastatin induces impairment in skeletal muscle while heart is protected.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Statin-induced muscle necrosis in the rat: distribution, development, and fibre selectivity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondrial reactive oxygen species and nitric oxide-mediated cancer cell apoptosis in 2-butylamino-2-demethoxyhypocrellin B photodynamic treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondrial ROS-induced ROS release: an update and review

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondria are morphologically and functionally heterogeneous within cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Smoking disturbs mitochondrial respiratory chain function and enhances lipid peroxidation on human circulating lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Naproxen affects Ca(2+) fluxes in mitochondria, microsomes and plasma membrane vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

The mitochondrial megachannel is the permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Simultaneous analysis of the majority of low-molecular-weight, redox-active compounds from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Superoxide-driven aconitase FE-S center cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondria and Ca(2+)in cell physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Seeing is believing: recent trends in the measurement of Ca2+ in subcellular domains and intracellular organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Assessment of mitochondrial membrane potential in situ using single potentiometric dyes and a novel fluorescence resonance energy transfer technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Screening assays for the mitochondrial permeability transition using a fluorescence multiwell plate reader

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Systematic identification of human mitochondrial disease genes through integrative genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

The use of a fluorescence-based oxygen uptake assay in the analysis of cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Animal models of human disease in drug safety assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

[13C]Methionine breath test: a novel method to detect antiretroviral drug-related mitochondrial toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.2.161

21 January 2018

Identifiers

DOI

10.1586/14737159.7.2.161

1 reference

16 August 2017

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