Metabonomics in pharmaceutical R&amp;D. (Q36735003)

16 August 2017

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title

Metabonomics in pharmaceutical R&D. (English)

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16 August 2017

Jeremy K Nicholson

3

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Elaine Holmes

series ordinal

2

object named as

Elaine Holmes

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16 August 2017

John C Lindon

1

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PubMed ID

17298438

16 August 2017

language of work or name

English

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publication date

1 March 2007

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16 August 2017

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16 August 2017

274

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16 August 2017

1140-1151

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16 August 2017

5

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'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

16 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabonomics: a platform for studying drug toxicity and gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabolic profiling of the effects of D-galactosamine in liver spheroids using (1)H NMR and MAS-NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Functional genomics via metabolic footprinting: monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Tissue targeted metabonomics: metabolic profiling by microdialysis sampling and microcoil NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabolomics – the link between genotypes and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Focused metabolomic profiling in the drug development process: advances from lipid profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Orthogonal projections to latent structures (O-PLS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Summary recommendations for standardization and reporting of metabolic analyses

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

A proposed framework for the description of plant metabolomics experiments and their results

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Experimental metabonomic model of dietary variation and stress interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Analytical reproducibility in (1)H NMR-based metabonomic urinalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Pharmaco-metabonomic phenotyping and personalized drug treatment

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

The challenges of modeling mammalian biocomplexity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Phenotype characterisation using integrated gene transcript, protein and metabolite profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Combination of 'omics' data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in rats and to identify potential biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

High resolution proton magnetic resonance spectroscopy of biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Cryogenic Probe13C NMR Spectroscopy of Urine for Metabonomic Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Toxicological applications of magnetic resonance

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

Toxicity classification from metabonomic data using a density superposition approach: ‘CLOUDS’

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

NMR Spectroscopy of Biofluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05673.X

10.1111/J.1742-4658.2007.05673.X

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17298438