Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development (Q30969083)

27 June 2017

Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development (English)

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27 June 2017

Directly coupled HPLC–NMR and HPLC–NMR–MS in pharmaceutical research and development (English)

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Jeremy K Nicholson

2

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author name string

Lindon JC

1

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27 June 2017

Nicholson JK

2

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27 June 2017

Wilson ID

3

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27 June 2017

John C Lindon

1

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Ian D Wilson

3

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publication date

1 October 2000

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Journal of Chromatography B: Biomedical Sciences and Applications

27 June 2017

October 2000

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published in

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27 June 2017

748

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27 June 2017

233-258

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27 June 2017

1

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Direct coupling of chromatographic separations to NMR spectroscopy

27 June 2017

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Online NMR detection of amino acids and peptides in microbore LC

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Capillary HPLC-NMR Coupling: High-Resolution (1)H NMR Spectroscopy in the Nanoliter Scale

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7 January 2021

Combined HPLC, NMR Spectroscopy, and Ion-Trap Mass Spectrometry with Application to the Detection and Characterization of Xenobiotic and Endogenous Metabolites in Human Urine

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7 January 2021

On-line liquid chromatography coupled with high field NMR and mass spectrometry (LC-NMR-MS): a new technique for drug metabolite structure elucidation

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7 January 2021

High-performance liquid chromatography/NMR spectrometry/mass spectrometry: further advances in hyphenated technology

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7 January 2021

Characterisation of impurities in bulk drug batches of fluticasone propionate using directly coupled HPLC–NMR spectroscopy and HPLC–MS

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7 January 2021

Application of LC-NMR and LC-MS to the identification of degradation products of a protease inhibitor in dosage formulations

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7 January 2021

Directly Coupled Chiral HPLC−NMR and HPLC−CD Spectroscopy as Complementary Methods for Structural and Enantiomeric Isomer Identification: Application to Atracurium Besylate

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7 January 2021

The search for biologically active secondary metabolites

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7 January 2021

Monoterpene Dimers fromLisianthius seemannii

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Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents

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Prenylated Flavanones fromMonotes engleri: On-line Structure Elucidation by LC/UV/NMR

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Identification of two isomeric meroterpenoid naphthoquinones fromCordia linnaei by liquid chromatography-mass spectrometry and liquid chromatography-nuclear magnetic resonance spectroscopy

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7 January 2021

Use of on-flow LC/1H NMR for the study of an antioxidant fraction from Orophea enneandra and isolation of a polyacetylene, lignans, and a tocopherol derivative

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7 January 2021

Determination of pyrrolizidine alkaloids in senecio species by liquid chromatography/thermospray-mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy.

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7 January 2021

Liquid chromatography-nuclear magnetic resonance spectroscopy

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7 January 2021

Application of high-performance liquid chromatography coupled to nuclear magnetic resonance spectrometry, mass spectrometry and bioassay for the determination of active saponins from Bacopa monniera Wettst

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Combination of LC-MS and LC-NMR as a Tool for the Structure Determination of Natural Products

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High-Performance Liquid Chromatography On-Line Coupled to High-Field NMR and Mass Spectrometry for Structure Elucidation of Constituents ofHypericum perforatumL.

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High performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy and mass spectrometry applied to plant products: Identification of ecdysteroids fromSilene otites

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7 January 2021

Characterization of Metabolites in IntactStreptomyces citricolorCulture Supernatants Using High-Resolution Nuclear Magnetic Resonance and Directly Coupled High-Pressure Liquid Chromatography–Nuclear Magnetic Resonance Spectroscopy

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7 January 2021

19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4- trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling

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7 January 2021

Investigation of the human metabolism of antipyrine using coupled liquid chromatography and nuclear magnetic resonance spectroscopy of urine

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7 January 2021

High-performance liquid chromatography coupled to high-field proton nuclear magnetic resonance spectroscopy: application to the urinary metabolites of ibuprofen

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7 January 2021

Coupling of HPLC with 19F- and 1H-NMR spectroscopy to investigate the human urinary excretion of flurbiprofen metabolites

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7 January 2021

Evaluation of liquid chromatography coupled with high-field 1H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile

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7 January 2021

Directly Coupled 800 MHz HPLC−NMR Spectroscopy of Urine and Its Application to the Identification of the Major Phase II Metabolites of Tolfenamic Acid

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7 January 2021

Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus

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7 January 2021

Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV).

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7 January 2021

Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat

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7 January 2021

Nuclear Magnetic Resonance and High-Performance Liquid Chromatography-Nuclear Magnetic Resonance Studies on the Toxicity and Metabolism of Ifosfamide

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7 January 2021

Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using 19F-NMR spectroscopy and directly coupled HPLCNMR-MS

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7 January 2021

Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: Application to N,N-dimethylformamide

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7 January 2021

Investigation of the feasibility of directly-coupled HPLC-NMR with 2H detection with application to the metabolism of N-dimethylformamide-d7

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7 January 2021

Characterization of in vitro metabolites from human liver microsomes using directly coupled hplc-nmr: application to a phenoxathiin monoamine oxidase-A inhibitor

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7 January 2021

750 MHz HPLC-NMR spectroscopic identification of rat microsomal metabolites of phenoxypyridines

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7 January 2021

Identification of the Positional Isomers of 2-Fluorobenzoic acid 1-O-Acyl Glucuronide by Directly Coupled HPLC-NMR

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Measurement of Internal Acyl Migration Reaction Kinetics Using Directly Coupled HPLC-NMR: Application for the Positional Isomers of Synthetic (2-Fluorobenzoyl)-d-glucopyranuronic Acid

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750-MHz directly coupled HPLC-NMR: Application for the sequential characterization of the positional isomers and anomers of 2-, 3-, and 4-fluorobenzoic acid glucuronides in equilibrium mixtures

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7 January 2021

750 MHz HPLC−NMR Spectroscopic Studies on the Separation and Characterization of the Positional Isomers of the Glucuronides of 6,11-Dihydro-11- oxodibenz[b,e]oxepin-2-acetic Acid

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7 January 2021

Direct characterization of drug glucuronide isomers in human urine by HPLC-NMR spectroscopy: application to the positional isomers of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide

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7 January 2021

High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat

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7 January 2021

NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man

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7 January 2021

Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct

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7 January 2021

High-Resolution NMR Spectroscopy of Sample Volumes from 1 nL to 10 &mgr;L

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7 January 2021

A Microcoil NMR Probe for Coupling Microscale HPLC with On-Line NMR Spectroscopy

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7 January 2021

Superheated Heavy Water as the Eluent for HPLC-NMR and HPLC-NMR-MS of Model Drugs

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7 January 2021

Capillary electrophoresis

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7 January 2021

1H-NMR Spectroscopy on the Nanoliter Scale for Static and Online Measurements

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7 January 2021

Directly coupled CZE-NMR and CEC-NMR spectroscopy for metabolite analysis: paracetamol metabolites in human urine

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7 January 2021

Size-exclusion chromatography with on-line ultraviolet, proton nuclear magnetic resonance and mass spectrometric detection and on-line collection for off-line Fourier transform infrared spectroscopy.

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7 January 2021

High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline

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7 January 2021

10.1016/S0378-4347(00)00320-0

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