Experimental approaches to the study of HIV-1 latency (Q36708954)

15 August 2017

title

Experimental approaches to the study of HIV-1 latency (English)

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15 August 2017

2

Megan Wind-Rotolo

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15 August 2017

5

Robert F Siliciano

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15 August 2017

4

Janet D Siliciano

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15 August 2017

3

Hung-Chih Yang

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15 August 2017

1

Yefei Han

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15 August 2017

publication date

1 February 2007

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Nature Reviews Microbiology

15 August 2017

language of work or name

English

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published in

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15 August 2017

volume

5

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15 August 2017

issue

2

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15 August 2017

page(s)

95-106

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publication type of scholarly work

15 August 2017

review article

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High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR

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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

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Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

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Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

21 January 2018

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Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy

21 January 2018

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The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy

21 January 2018

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Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

21 January 2018

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Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence

21 January 2018

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Decay characteristics of HIV-1-infected compartments during combination therapy

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Early establishment of a pool of latently infected, resting CD4 + T cells during primary HIV-1 infection

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Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1.

21 January 2018

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Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART

21 January 2018

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Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy

21 January 2018

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Effects of prostratin on T-cell activation and human immunodeficiency virus latency

21 January 2018

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Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype

21 January 2018

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Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir

21 January 2018

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

21 January 2018

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A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children

21 January 2018

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Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1580

Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1580

Molecular Characterization, Reactivation, and Depletion of Latent HIV

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1580

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Control of CD4+ T-cell memory by cytokines and costimulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Viral dynamics in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Human immunodeficiency virus long terminal repeat responds to T-cell activation signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1580

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Biphasic decay of latently infected CD4+ T cells in acute human immunodeficiency virus type 1 infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1580

A quantitative assay for HIV DNA integration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

A sensitive, quantitative assay for human immunodeficiency virus type 1 integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV-1 integration in the human genome favors active genes and local hotspots

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Analysis of human immunodeficiency virus type 1 integration by using a specific, sensitive and quantitative assay based on real-time polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

G-->A hypermutation in protease and reverse transcriptase regions of human immunodeficiency virus type 1 residing in resting CD4+ T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The multifactorial nature of HIV-1 latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

NF-kappa B-dependent and -independent pathways of HIV activation in a chronically infected T cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Genomic sites of human immunodeficiency virus type 2 (HIV-2) integration: similarities to HIV-1 in vitro and possible differences in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Generation of HIV latency during thymopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

In vivo activation of antigen-specific CD4 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Differential T cell receptor-mediated signaling in naive and memory CD4 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

HIV Quasispecies and Resampling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Time of initiation of antiretroviral therapy: impact on HIV-1 viraemia. The Swiss HIV Cohort Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

Nonproductive human immunodeficiency virus type 1 infection in nucleoside-treated G0 lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

7 January 2021

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

7 January 2021

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

7 January 2021

Mutations in thetatGene Are Responsible for Human Immunodeficiency Virus Type 1 Postintegration Latency in the U1 Cell Line

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1580

7 January 2021

Identifiers

DOI

10.1038/NRMICRO1580

1 reference

Dimensions publication ID

15 August 2017

1000083480

0 references

1 reference