Neem oil limonoids induces p53-independent apoptosis and autophagy. (Q36647000)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22915764%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Neem oil limonoids induces p53-independent apoptosis and autophagy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22915764%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

0 references

10

1 reference

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11 February 2020

Dhyan Chandra

11

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11 February 2020

author name string

Pragya Srivastava

1

1 reference

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11 February 2020

Neelu Yadav

2

1 reference

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11 February 2020

Ravi Lella

3

1 reference

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11 February 2020

Andrea Schneider

4

1 reference

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11 February 2020

Anthony Jones

5

1 reference

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11 February 2020

Timothy Marlowe

6

1 reference

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11 February 2020

Gabrielle Lovett

7

1 reference

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11 February 2020

Kieran O'Loughlin

8

1 reference

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11 February 2020

Hans Minderman

9

1 reference

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11 February 2020

language of work or name

English

0 references

publication date

21 August 2012

1 reference

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11 February 2020

1 reference

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11 February 2020

volume

33

1 reference

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11 February 2020

page(s)

2199-2207

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11 February 2020

issue

11

1 reference

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Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

11 February 2020

cites work

1 reference

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Anticancer biology of Azadirachta indica L (neem): a mini review

30 September 2017

1 reference

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Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.

30 September 2017

1 reference

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Mitochondrial dysfunction impairs tumor suppressor p53 expression/function

30 September 2017

1 reference

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Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).

30 September 2017

1 reference

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Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation

30 September 2017

1 reference

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Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis

30 September 2017

1 reference

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The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

30 September 2017

1 reference

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Autophagy regulation by p53.

30 September 2017

1 reference

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Functional evidence that the self-renewal gene NANOG regulates human tumor development

30 September 2017

1 reference

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PUMA- and Bax-induced autophagy contributes to apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Potential therapeutic applications of autophagy

30 September 2017

1 reference

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The apoptosome: signalling platform of cell death

30 September 2017

1 reference

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Autophagy and cell death.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Expression of PCNA, cytokeratin, Bcl-2 and p53 during chemoprevention of hamster buccal pouch carcinogenesis by ethanolic neem (Azadirachta indica) leaf extract

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Bioenergetic aspects of apoptosis, necrosis and mitoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems

30 September 2017

1 reference

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Autophagy as a cell death and tumor suppressor mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Role of BAX in the apoptotic response to anticancer agents

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

30 September 2017

1 reference

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Clinical implications of p53 mutations

30 September 2017

1 reference

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Molecular characterization of mitochondrial apoptosis-inducing factor

30 September 2017

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Apoptotic pathways: the roads to ruin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Death receptors: signaling and modulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Two CD95 (APO-1/Fas) signaling pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Bortezomib activity and in vitro interactions with anthracyclines and cytarabine in acute myeloid leukemia cells are independent of multidrug resistance mechanisms and p53 status.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Serum cytochrome c indicates in vivo apoptosis and can serve as a prognostic marker during cancer therapy.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Early mitochondrial activation and cytochrome c up-regulation during apoptosis

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584965

Actin cytoskeleton as a putative target of the neem limonoid Azadirachtin A

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22915764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell-cycle arrest versus cell death in cancer therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22915764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22915764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/CARCIN/BGS269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22915764%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22915764%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22915764%20AND%20SRC:MED&resulttype=core&format=json