Alzheimer disease--no target for statin treatment. A mini review (Q36634036)

15 August 2017

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title

Alzheimer disease--no target for statin treatment. A mini review (English)

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15 August 2017

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2

Peter Riederer

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15 August 2017

Siegfried Hoyer

1

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15 August 2017

25 October 2006

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15 August 2017

Neurochemical Research

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15 August 2017

32

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15 August 2017

4-5

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15 August 2017

695-706

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https://scigraph.springernature.com/pub.10.1007/s11064-006-9168-x

15 August 2017

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cites work

Midlife cardiovascular risk factors and risk of dementia in late life

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

Intracellular cholesterol transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

Recent advances in membrane cholesterol domain dynamics and intracellular cholesterol trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

Cell damage in the brain: a speculative synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

21 January 2018

ATP and brain function

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

Cholesterol attenuates the membrane perturbing properties of beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

Cholesterol and neuropathologic markers of AD: a population-based autopsy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-006-9168-X

High total cholesterol levels in late life associated with a reduced risk of dementia.

21 January 2018

1 reference

12 December 2020

Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains

1 reference

12 December 2020

Copernicus revisited: amyloid beta in Alzheimer's disease

1 reference

12 December 2020

The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease

1 reference

12 December 2020

The differentiation of phospholipase A1 and A2 in rat and human nervous tissues

1 reference

12 December 2020

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

1 reference

12 December 2020

Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease.

1 reference

12 December 2020

Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice.

1 reference

12 December 2020

Statins and the risk of dementia

1 reference

12 December 2020

Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.

1 reference

12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

12 December 2020

Brain Cholesterol, Statins and Alzheimer’s Disease

1 reference

12 December 2020

Phospholipid Methylation and Biological Signal Transmission

1 reference

12 December 2020

The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

1 reference

12 December 2020

Membrane lipid composition and cellular function

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Membrane disruption by Alzheimer beta-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neurotoxicity.

1 reference

12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

12 December 2020

GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain.

1 reference

12 December 2020

Apolipoprotein E polymorphism and atherosclerosis

1 reference

12 December 2020

Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease

1 reference

12 December 2020

Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death

1 reference

12 December 2020

Metabolic processes in Alzheimer's disease: adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex.

1 reference

12 December 2020

Statins: drugs for Alzheimer's disease?

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12 December 2020

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

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12 December 2020

Lipid compositions of different regions of the human brain during aging.

1 reference

12 December 2020

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

1 reference

12 December 2020

Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

1 reference

12 December 2020

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

1 reference

12 December 2020

Statin therapy in Alzheimer's disease

1 reference

12 December 2020

Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

1 reference

12 December 2020

Clinical deterioration in probable Alzheimer's disease correlates with progressive metabolic impairment of association areas.

1 reference

12 December 2020

The lipid compositions of different regions of rat brain during development and aging.

1 reference

12 December 2020

31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease

1 reference

12 December 2020

Cellular cholesterol efflux mediated by cyclodextrins

1 reference

12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

12 December 2020

Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition

1 reference

12 December 2020

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

1 reference

12 December 2020

Alzheimer's disease: the cholesterol connection

1 reference

12 December 2020

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

1 reference

12 December 2020

Cholesterol and Alzheimer's disease: statins, cholesterol depletion in APP processing and Abeta generation.

1 reference

12 December 2020

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

1 reference

12 December 2020

Increased caveolin-1 expression in Alzheimer's disease brain

1 reference

12 December 2020

The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress

1 reference

12 December 2020

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

1 reference

12 December 2020

Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type

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12 December 2020

Molecular insights into neurodevelopmental and neurodegenerative diseases

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12 December 2020

Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids

1 reference

12 December 2020

A detergent-insoluble membrane compartment contains A beta in vivo.

1 reference

12 December 2020

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

12 December 2020

APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study.

1 reference

12 December 2020

Apolipoprotein E: far more than a lipid transport protein

1 reference

12 December 2020

CNS synaptogenesis promoted by glia-derived cholesterol

1 reference

12 December 2020

Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice

1 reference

12 December 2020

Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation

1 reference

12 December 2020

Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease

1 reference

12 December 2020

Oxidative energy metabolism in Alzheimer brain

1 reference

12 December 2020

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

1 reference

12 December 2020

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

1 reference

12 December 2020

Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.

1 reference

12 December 2020

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

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12 December 2020

Role of the AMP-activated protein kinase in the cellular stress response

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12 December 2020

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

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12 December 2020

Cholesterol-dependent modulation of tau phosphorylation in cultured neurons

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12 December 2020

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

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12 December 2020

3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain

1 reference

12 December 2020

Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease

1 reference

12 December 2020

Cholesterol, statins and dementia.

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12 December 2020

Cholesterol homeostasis in neurons and glial cells

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12 December 2020

Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease

1 reference

12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

1 reference

12 December 2020

Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein

1 reference

12 December 2020

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

12 December 2020

Gene dose effect of the APOE-epsilon4 allele on plasma HDL cholesterol level in patients with Alzheimer's disease

1 reference

12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

12 December 2020

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1 reference

12 December 2020

Lipid rafts and signal transduction

1 reference

12 December 2020

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

1 reference

12 December 2020

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases

1 reference

12 December 2020

Essential role for cholesterol in synaptic plasticity and neuronal degeneration

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12 December 2020

Presynaptic cholinergic dysfunction in patients with dementia.

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12 December 2020

New insights into the pharmacodynamic and pharmacokinetic properties of statins.

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12 December 2020

Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy

1 reference

12 December 2020

A study of statin use in the prevention of cognitive impairment of vascular origin in the UK.

1 reference

12 December 2020

Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase

1 reference

12 December 2020

Statin effects on cholesterol micro-domains in brain plasma membranes

1 reference

12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

1 reference

12 December 2020

Cholesterol, transferrin saturation, and the development of dementia and Alzheimer's disease: results from an 18-year population-based cohort.

1 reference

12 December 2020

Differences of regional cerebral glucose metabolism between presenile and senile dementia of Alzheimer type

1 reference

12 December 2020

Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).

1 reference

12 December 2020

New frontiers in Alzheimer's disease genetics

1 reference

12 December 2020

Serum lipids and hippocampal volume: the link to Alzheimer's disease?

1 reference

12 December 2020

Intracellular trafficking of cholesterol monitored with a cyclodextrin

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12 December 2020

Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides.

1 reference

12 December 2020

Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease.

1 reference

12 December 2020

Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.

1 reference

12 December 2020

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

1 reference

12 December 2020

Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol.

1 reference

12 December 2020

Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.

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12 December 2020

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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12 December 2020

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

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12 December 2020

Membrane lipids in the aging human brain.

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12 December 2020

Glucocorticoid-related genetic susceptibility for Alzheimer's disease.

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12 December 2020

Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons.

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein

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12 December 2020

Role of cholesterol in membranes. Effects on phospholipid-protein interactions, membrane permeability and enzymatic activity

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12 December 2020

Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years.

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12 December 2020

Evidence for a membrane defect in Alzheimer disease brain

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12 December 2020

10.1007/S11064-006-9168-X

Identifiers

DOI

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15 August 2017

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PubMed ID

17063393