Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease (Q28201917)

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D Lütjohann

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M Ludwig

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A Schulte

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U Ptok

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F Jessen

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K von Bergmann

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M L Rao

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R Heun

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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language of work or name

English

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publication date

2002

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published in

Molecular Psychiatry

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volume

7

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issue

8

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page(s)

899-902

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cites work

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Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

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The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimer's disease.

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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Cholesterol from degenerating nerve myelin becomes associated with lipoproteins containing apolipoprotein E.

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Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

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The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells.

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Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta

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24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

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Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid

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Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.

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Cholesterol for synthesis of myelin is made locally, not imported into brain

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7 January 2021

Platelet monoamine oxidase activity is related to MAOB intron 13 genotype

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Free radicals and reactive oxygen species in programmed cell death

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Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

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