RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR. (Q36619492)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22976291%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR (English)

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13 February 2020

1

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13 February 2020

author name string

Chelsea Mooser

2

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13 February 2020

Christine M Janson

3

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13 February 2020

Joanne M Bliss

4

1 reference

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13 February 2020

Houmehr Hojjat

5

1 reference

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13 February 2020

John Colicelli

6

1 reference

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13 February 2020

language of work or name

English

0 references

publication date

12 September 2012

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13 February 2020

published in

Journal of Cell Science

1 reference

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13 February 2020

volume

125

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13 February 2020

issue

Pt 23

1 reference

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13 February 2020

page(s)

5887-5896

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Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis

13 February 2020

cites work

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c-Cbl-mediated selective virus-receptor translocations into lipid rafts regulate productive Kaposi's sarcoma-associated herpesvirus infection in endothelial cells.

30 September 2017

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Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

30 September 2017

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Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta

30 September 2017

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Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies

30 September 2017

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ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.

30 September 2017

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ABL tyrosine kinases: evolution of function, regulation, and specificity

30 September 2017

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Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex

30 September 2017

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Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination

30 September 2017

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Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

30 September 2017

1 reference

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Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells

30 September 2017

1 reference

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Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors

30 September 2017

1 reference

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Differential effects of EGFR ligands on endocytic sorting of the receptor.

30 September 2017

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Functional determinants of ras interference 1 mutants required for their inhbitory activity on endocytosis

30 September 2017

1 reference

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Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins

30 September 2017

1 reference

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Inhibition of early endosome fusion by Rab5-binding defective Ras interference 1 mutants

30 September 2017

1 reference

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H. pylori selectively blocks EGFR endocytosis via the non-receptor kinase c-Abl and CagA.

30 September 2017

1 reference

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Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop.

30 September 2017

1 reference

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Cellular localization of the activated EGFR determines its effect on cell growth in MDA-MB-468 cells

30 September 2017

1 reference

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Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms

30 September 2017

1 reference

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Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Multivesicular bodies: co-ordinated progression to maturity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

RIN1 is a breast tumor suppressor gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

EGF receptor ubiquitination is not necessary for its internalization

30 September 2017

1 reference

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Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival

30 September 2017

1 reference

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Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation

30 September 2017

1 reference

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Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis

30 September 2017

1 reference

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Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor

30 September 2017

1 reference

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Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

30 September 2017

1 reference

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The Cbl interactome and its functions

30 September 2017

1 reference

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Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction

30 September 2017

1 reference

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Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells

30 September 2017

1 reference

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RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.

30 September 2017

1 reference

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Human RAS superfamily proteins and related GTPases

30 September 2017

1 reference

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The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

30 September 2017

1 reference

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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.

30 September 2017

1 reference

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The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

30 September 2017

1 reference

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Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

30 September 2017

1 reference

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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

30 September 2017

1 reference

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

30 September 2017

1 reference

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

30 September 2017

1 reference

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The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain

30 September 2017

1 reference

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Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Epidermal growth factor regulates the expression of its own receptor

30 September 2017

1 reference

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rab5 controls early endosome fusion in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration

30 September 2017

1 reference

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UVC modulation of epidermal growth factor receptor number in HeLa S3 cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Recycling of cell surface pro-transforming growth factor-{alpha} regulates epidermal growth factor receptor activation.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Role of rab5 in EGF receptor-mediated signal transduction

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575715

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22976291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22976291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Visualization of actin dynamics during macropinocytosis and exocytosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22976291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/JCS.113688

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22976291%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22976291%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference