The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B. (Q36606151)

15 August 2017

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B. (English)

1 reference

15 August 2017

3

Ruth Nussinov

1 reference

15 August 2017

2

Hyunbum Jang

1 reference

15 August 2017

Shaoyong Lu

1

1 reference

PMCID

4763299

15 August 2017

Jian Zhang

series ordinal

4

1 reference

PMCID

4763299

15 August 2017

language of work or name

English

0 references

publication date

23 February 2016

1 reference

15 August 2017

1 reference

15 August 2017

6

1 reference

15 August 2017

21949

1 reference

https://scigraph.springernature.com/pub.10.1038/srep21949

15 August 2017

0 references

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The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

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GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

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Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm

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Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations.

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The Role of Conformational Dynamics and Allostery in the Disease Development of Human Ferritin

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Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays

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Stability of Iowa mutant and wild type Aβ-peptide aggregates

30 September 2017

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Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant

30 September 2017

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Drugging the undruggable RAS: Mission possible?

30 September 2017

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The structural basis for cancer treatment decisions

30 September 2017

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The structural basis of ATP as an allosteric modulator

30 September 2017

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Communication routes in ARID domains between distal residues in helix 5 and the DNA-binding loops

30 September 2017

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P-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscape

30 September 2017

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Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics

30 September 2017

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Small-molecule modulation of Ras signaling

30 September 2017

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Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.

30 September 2017

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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

30 September 2017

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Harnessing allostery: a novel approach to drug discovery

30 September 2017

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KRAS: feeding pancreatic cancer proliferation

30 September 2017

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

30 September 2017

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NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

30 September 2017

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30 September 2017

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Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations

30 September 2017

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A comprehensive survey of Ras mutations in cancer

30 September 2017

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

30 September 2017

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

30 September 2017

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Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

30 September 2017

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Nucleotide binding switches the information flow in ras GTPases

30 September 2017

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The distinct conformational dynamics of K-Ras and H-Ras A59G

30 September 2017

1 reference

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

30 September 2017

1 reference

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Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics

30 September 2017

1 reference

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Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763299

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

30 September 2017

1 reference

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Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf

30 September 2017

1 reference

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GEFs and GAPs: critical elements in the control of small G proteins

30 September 2017

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30 September 2017

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Structural analysis of autoinhibition in the Ras activator Son of sevenless

30 September 2017

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The structural basis for the transition from Ras-GTP to Ras-GDP

30 September 2017

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The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.

30 September 2017

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

30 September 2017

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Structural basis for the interaction of Ras with RalGDS

30 September 2017

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Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21.

30 September 2017

1 reference

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

30 September 2017

1 reference

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Ras/Rap effector specificity determined by charge reversal

30 September 2017

1 reference

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

30 September 2017

1 reference

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The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation

30 September 2017

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Self-guided Langevin dynamics study of regulatory interactions in NtrC.

28 June 2018

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Differential dynamics of RAS isoforms in GDP- and GTP-bound states.

28 June 2018

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Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate.

20 September 2018

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The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?

20 September 2018

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Structure of a transient intermediate for GTP hydrolysis by ras.

20 September 2018

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Revisiting the structural flexibility of the complex p21(ras)-GTP: the catalytic conformation of the molecular switch II.

20 September 2018

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Comparison of simple potential functions for simulating liquid water

20 September 2018

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https://api.crossref.org/works/10.1038%2FSREP21949

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

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RAS's cloak of invincibility slips at last?

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26902995

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26902995

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP21949

1 reference

15 August 2017

1 reference

15 August 2017

1 reference

PMCID

4763299