The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP. (Q35926620)

11 August 2017

The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP. (English)

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11 August 2017

Resat H

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11 August 2017

Straatsma TP

series ordinal

2

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11 August 2017

Dixon DA

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3

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11 August 2017

Miller JH

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4

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11 August 2017

language of work or name

English

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publication date

1 May 2001

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Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

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11 August 2017

98

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11 August 2017

11

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11 August 2017

6033-6038

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Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

The GTP binding motif: variations on a theme

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Function and regulation of ras.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Prediction of pH-dependent properties of proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Signal transduction pathways involving Ras. Mini review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Purification of ras GTPase activating protein from bovine brain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

ras oncogenes in human cancer: a review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

The GTPase superfamily: a conserved switch for diverse cell functions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

The GTPase superfamily: conserved structure and molecular mechanism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Why have mutagenesis studies not located the general base in ras p21.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Differential regulation of rasGAP and neurofibromatosis gene product activities

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Probing the structure and mechanism of Ras protein with an expanded genetic code

11 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33417

Electrostatics and diffusion of molecules in solution: simulations with the University of Houston Brownian Dynamics program

24 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Simulation of the solution structure of the H-ras p21-GTP complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

How do the GTPases really work?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Molecular cloning of two types of GAP complementary DNA from human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.091506998

21 January 2018

Identifiers

DOI

10.1073/PNAS.091506998

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11 August 2017

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11 August 2017

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