Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche? (Q36599294)

15 August 2017

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title

Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche? (English)

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15 August 2017

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Aleksandra Rizo

1

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15 August 2017

Edo Vellenga

series ordinal

2

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15 August 2017

Gerald de Haan

series ordinal

3

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15 August 2017

Jan Jacob Schuringa

series ordinal

4

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15 August 2017

1 October 2006

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15 August 2017

Human Molecular Genetics

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15 August 2017

15 Spec No 2

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15 August 2017

R210-9

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A direct measurement of the radiation sensitivity of normal mouse bone marrow cells

15 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for Clinical Application

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Hematopoietic stem cells do not engraft with absolute efficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Osteoblastic cells regulate the haematopoietic stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Identification of the haematopoietic stem cell niche and control of the niche size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Cancer stem cells: lessons from leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

MUC1 mediates transendothelial migration in vitro by ligating endothelial cell ICAM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Fibroblast growth factor-1 and -2 preserve long-term repopulating ability of hematopoietic stem cells in serum-free cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Role of polycomb group proteins in stem cell self-renewal and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Stabilization of chromatin structure by PRC1, a Polycomb complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Chromatin signatures of pluripotent cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Hox homeobox genes as regulators of normal and leukemic hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Platelet factor 4 enhances the adhesion of normal and leukemic hematopoietic stem/progenitor cells to endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

MEK kinase 1 mediates the antiapoptotic effect of the Bcr-Abl oncogene through NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Chronic myeloid leukaemia: stem cell derived but progenitor cell driven

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

BCR-ABL-induced adhesion defects are tyrosine kinase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Efficient long-term maintenance of chronic myeloid leukemic cobblestone area forming cells on a murine stromal cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

STAT5 signaling is required for the efficient induction and maintenance of CML in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

21 January 2018

Role of FLT3 in leukemia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Converging pathways in leukemogenesis and stem cell self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

More than just proliferation: Myc function in stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL175

21 January 2018

Identifiers

DOI

10.1093/HMG/DDL175

1 reference

15 August 2017

1 reference