Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes (Q36587959)

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scientific article published on 5 December 2012

Language	Label	Description	Also known as
English	Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes	scientific article published on 5 December 2012

Statements

scholarly article

1 reference

Europe PubMed Central

15 August 2017

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes (English)

1 reference

Europe PubMed Central

15 August 2017

endoplasmic reticulum

1 reference

based on heuristic

inferred from title

protein ubiquitination

1 reference

based on heuristic

inferred from title

author name string

Youngah Jo

1

1 reference

Europe PubMed Central

15 August 2017

Isamu Z Hartman

2

1 reference

Europe PubMed Central

15 August 2017

Russell A DeBose-Boyd

3

1 reference

Europe PubMed Central

15 August 2017

publication date

5 December 2012

1 reference

Europe PubMed Central

15 August 2017

Molecular Biology of the Cell

1 reference

Europe PubMed Central

15 August 2017

24

1 reference

Europe PubMed Central

15 August 2017

3

1 reference

Europe PubMed Central

15 August 2017

169-183

1 reference

Europe PubMed Central

15 August 2017

Lipid droplets and cellular lipid metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

1 reference

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Not just fat: the structure and function of the lipid droplet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

1 reference

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9 September 2017

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

9 September 2017

Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway

1 reference

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Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

1 reference

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SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

1 reference

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UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

1 reference

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Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies.

1 reference

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Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

1 reference

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Lipid droplets: a unified view of a dynamic organelle

1 reference

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Protein sensors for membrane sterols

1 reference

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The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site

1 reference

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9 September 2017

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3564538

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Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

1 reference

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Membrane topology of human insig-1, a protein regulator of lipid synthesis

1 reference

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Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding

1 reference

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Mechanism of ubiquitin recognition by the CUE domain of Vps9p

1 reference

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

1 reference

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

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Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23223569

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Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces sp

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Identifiers

10.1091/MBC.E12-07-0564

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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