Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease? (Q36585041)

15 August 2017

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title

Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease? (English)

1 reference

15 August 2017

Ingo H Tarner

1

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PubMed ID

16951704

15 August 2017

C Garrison Fathman

series ordinal

2

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PubMed ID

16951704

15 August 2017

language of work or name

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1 September 2006

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Nature Clinical Practice Rheumatology

15 August 2017

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15 August 2017

2

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15 August 2017

9

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15 August 2017

491-499

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Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

15 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Differentiation of regulatory T cells 1 is induced by CD2 costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Metastable tolerance in nonhuman primates and humans.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Monoclonal antibody therapy in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Long-lived plasma cells and their contribution to autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Treatment of rheumatoid arthritis with single dose or weekly pulses of chimaeric anti-CD4 monoclonal antibody

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Antigen microarray profiling of autoantibodies in rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Stem cells engineered to express self-antigen to treat autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Treatment of severe autoimmune disease by stem-cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

The role of CD154 in organ transplant rejection and acceptance

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

1 reference

7 January 2021

CD4(+)CD25(+) T cells facilitate the induction of T cell anergy

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

The contributions of T-cell anergy to peripheral T-cell tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Transactivation by AP-1 is a molecular target of T cell clonal anergy

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Blocked Ras activation in anergic CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Negative transcriptional regulation in anergic T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

E3 ubiquitin ligases as T cell anergy factors.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

1 reference

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

1 reference

7 January 2021

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Cbl-b regulates the CD28 dependence of T-cell activation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

In vivo instruction of suppressor commitment in naive T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

An essential role for Scurfin in CD4+CD25+ T regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Type 1 T regulatory cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Inducing and expanding regulatory T cell populations by foreign antigen

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Role of LAG-3 in regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0272

7 January 2021

Identifiers

DOI

10.1038/NCPRHEUM0272

1 reference

15 August 2017

1 reference

PubMed ID

16951704