Pharmacokinetic considerations in the treatment of CNS tumours (Q36574934)

15 August 2017

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title

Pharmacokinetic considerations in the treatment of CNS tumours (English)

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15 August 2017

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Susannah Motl

1

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15 August 2017

Yanli Zhuang

series ordinal

2

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15 August 2017

Christopher M Waters

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3

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15 August 2017

Clinton F Stewart

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4

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15 August 2017

1 January 2006

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Clinical Pharmacokinetics

15 August 2017

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15 August 2017

45

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15 August 2017

871-903

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15 August 2017

9

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https://scigraph.springernature.com/pub.10.2165/00003088-200645090-00002

15 August 2017

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cites work

Blood-brain barrier: interface between internal medicine and the brain

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200645090-00002

Choroid plexus in the central nervous system: biology and physiopathology

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200645090-00002

Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic

21 January 2018

1 reference

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https://api.crossref.org/works/10.2165%2F00003088-200645090-00002

Cerebrospinal fluid penetration of active metabolites of cyclophosphamide and ifosfamide in rhesus monkeys

21 January 2018

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12 December 2020

Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis.

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12 December 2020

Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat.

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12 December 2020

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.

1 reference

12 December 2020

Changes in blood-brain barrier permeability induced by radiotherapy: implications for timing of chemotherapy? (Review).

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12 December 2020

A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

1 reference

12 December 2020

Increased teniposide clearance with concomitant anticonvulsant therapy

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12 December 2020

Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression

1 reference

12 December 2020

Low concentrations of STI571 in the cerebrospinal fluid: a case report

1 reference

12 December 2020

Altered central nervous system pharmacology of methotrexate in childhood leukemia: another sign of meningeal relapse

1 reference

12 December 2020

Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children.

1 reference

12 December 2020

Clinical trials of P-glycoprotein reversal in solid tumours

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12 December 2020

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

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12 December 2020

Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

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12 December 2020

Neurological toxicity of ifosfamide

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12 December 2020

MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors.

1 reference

12 December 2020

Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice

1 reference

12 December 2020

Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat.

1 reference

12 December 2020

Penetration of intra-arterially administered vincristine in experimental brain tumor

1 reference

12 December 2020

Central nervous system pharmacokinetics of high-dose cytosine arabinoside.

1 reference

12 December 2020

Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.

1 reference

12 December 2020

Heterogeneity in the expression of markers for drug resistance in brain tumors.

1 reference

12 December 2020

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12 December 2020

Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

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12 December 2020

Interactions between antiepileptic and chemotherapeutic drugs

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12 December 2020

Vincristine effect on methotrexate cerebrospinal fluid concentration

1 reference

12 December 2020

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

1 reference

12 December 2020

Uptake of adriamycin in tumour and surrounding brain tissue in patients with malignant gliomas

1 reference

12 December 2020

Pharmacokinetics of vincristine in the cerebrospinal fluid of humans

1 reference

12 December 2020

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

1 reference

12 December 2020

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

1 reference

12 December 2020

Preirradiation paclitaxel in glioblastoma multiforme: efficacy, pharmacology, and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium

1 reference

12 December 2020

A primate model for study of methotrexate pharmacokinetics in the central nervous system

1 reference

12 December 2020

The structure of the choroid plexus and the physiology of the choroid plexus epithelium

1 reference

12 December 2020

Distribution and toxic effects of intravenously injected epirubicin on the central nervous system of the mouse

1 reference

12 December 2020

The blood-brain barrier: bottleneck in brain drug development

1 reference

12 December 2020

High-dose methotrexate in acute lymphocytic leukemia

1 reference

12 December 2020

Efflux transport systems for organic anions and cations at the blood-CSF barrier

1 reference

12 December 2020

Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor

1 reference

12 December 2020

Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier

1 reference

12 December 2020

Distribution and excretion of (3H)vincristine in the rat and the dog

1 reference

12 December 2020

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

1 reference

12 December 2020

Phase 2 study of idarubicin in pediatric brain tumors: Pediatric Oncology Group study POG 9237.

1 reference

12 December 2020

Estimating the world cancer burden: Globocan 2000.

1 reference

12 December 2020

Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates

1 reference

12 December 2020

Methotrexate cerebrospinal fluid and serum concentrations after intermediate-dose methotrexate infusion

1 reference

12 December 2020

Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route

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12 December 2020

CAR: detailing new models

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12 December 2020

Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections

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12 December 2020

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

1 reference

12 December 2020

CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid

1 reference

12 December 2020

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

1 reference

12 December 2020

The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice

1 reference

12 December 2020

Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa.

1 reference

12 December 2020

Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport

1 reference

12 December 2020

Blood-brain barrier permeation: molecular parameters governing passive diffusion

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12 December 2020

The accumulation of topotecan in 9L glioma and in brain parenchyma with and without dexamethasone administration.

1 reference

12 December 2020

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918.

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12 December 2020

Influence of schedule of administration on methotrexate penetration in brain tumours.

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12 December 2020

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

1 reference

12 December 2020

Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study

1 reference

12 December 2020

Cytosine arabinoside cerebrospinal fluid kinetics

1 reference

12 December 2020

Increased 9-aminocamptothecin dose requirements in patients on anticonvulsants. NABTT CNS Consortium. The New Approaches to Brain Tumor Therapy.

1 reference

12 December 2020

P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy

1 reference

12 December 2020

Influence of C6 and CNS1 brain tumors on methotrexate pharmacokinetics in plasma and brain tissue.

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12 December 2020

Concentration of vinblastine in human intracerebral tumor and other tissues.

1 reference

12 December 2020

Gefitinib reverses breast cancer resistance protein-mediated drug resistance

1 reference

12 December 2020

Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis

1 reference

12 December 2020

Epidemiology of brain tumors in childhood--a review

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12 December 2020

Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients

1 reference

12 December 2020

Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy

1 reference

12 December 2020

Vascular microenvironment in gliomas

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12 December 2020

Intrathecal administration of 4-hydroperoxycyclophosphamide in rhesus monkeys.

1 reference

12 December 2020

Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view

1 reference

12 December 2020

Pharmacokinetics of undiluted or diluted high-dose etoposide with or without busulfan administered to patients with hematologic malignancies

1 reference

12 December 2020

Chemotherapeutic agent permeability to normal brain and delivery to avian sarcoma virus-induced brain tumors in the rodent: observations on problems of drug delivery

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12 December 2020

Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles.

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12 December 2020

Active transport of methotrexate from cerebrospinal fluid in humans

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12 December 2020

Postnatal developmental changes in blood flow to choroid plexuses and cerebral cortex of the rat.

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12 December 2020

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice

1 reference

12 December 2020

Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes

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12 December 2020

In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats.

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12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

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12 December 2020

Irinotecan therapy in adults with recurrent or progressive malignant glioma.

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12 December 2020

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

12 December 2020

Comparison of serum and cerebrospinal fluid levels of methotrexate in man during high-dose chemotherapy for aggressive non-Hodgkin's lymphoma

1 reference

12 December 2020

Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux

1 reference

12 December 2020

A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia

1 reference

12 December 2020

Influence of phenytoin on the disposition of irinotecan: a case report

1 reference

12 December 2020

Dynamics of CNS barriers: evolution, differentiation, and modulation

1 reference

12 December 2020

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

1 reference

12 December 2020

Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours

1 reference

12 December 2020

Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.

1 reference

12 December 2020

P-glycoprotein expression on acute myeloid leukaemia blast cells at diagnosis predicts response to chemotherapy and survival

1 reference

12 December 2020

Pharmacokinetics of ifosfamide and some metabolites in children.

1 reference

12 December 2020

Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy

1 reference

12 December 2020

The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historical - and futuristic - perspective

1 reference

12 December 2020

Cyclophosphamide plasma and cerebrospinal fluid kinetics with and without dimethyl sulfoxide

1 reference

12 December 2020

Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients

1 reference

12 December 2020

Cerebrospinal fluid and plasma pharmacokinetics of high doses of 1-beta-D-arabinofuranosylcytosine in nonhuman primates

1 reference

12 December 2020

In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier.

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12 December 2020

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

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12 December 2020

Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors.

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12 December 2020

Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats

1 reference

12 December 2020

Prediction of blood-brain barrier penetration: are we missing the point?

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12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of intravenous temozolomide in non-human primates

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12 December 2020

Profiles of methotrexate in blood and CSF following intranasal and intravenous administration to rats

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12 December 2020

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

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12 December 2020

Methotrexate cerebrospinal fluid pharmacokinetics in a patient with lymphoma treated with methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone

1 reference

12 December 2020

The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.

1 reference

12 December 2020

A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy

1 reference

12 December 2020

Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.

1 reference

12 December 2020

Distribution and metabolism of vincristine in mice, rats, dogs, and monkeys

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12 December 2020

Pharmacokinetics and cerebrospinal fluid penetration of daunorubicin, idarubicin, and their metabolites in the nonhuman primate model

1 reference

12 December 2020

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein

1 reference

12 December 2020

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

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12 December 2020

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

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12 December 2020

Effect of P-glycoprotein modulation with cyclosporin A on cerebrospinal fluid penetration of doxorubicin in non-human primates.

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12 December 2020

Comparative brain tissue distribution of camptothecin and topotecan in the rat.

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12 December 2020

Cerebrospinal fluid and plasma concentrations of busulfan during high-dose therapy

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12 December 2020

Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors

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12 December 2020

Drug resistance in brain diseases and the role of drug efflux transporters.

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12 December 2020

Cerebrospinal fluid concentrations of carboplatin in a patient without blood-brain barrier disruption

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12 December 2020

Disposition and pharmacokinetics of temozolomide in rat.

1 reference

12 December 2020

Clinical pharmacology of isophosphamide

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12 December 2020

Cancer multidrug resistance: a review of recent drug discovery research.

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12 December 2020

A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid.

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12 December 2020

Neoplastic Meningitis

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12 December 2020

Central nervous system failure in patients with chronic myelogenous leukemia lymphoid blast crisis and Philadelphia chromosome positive acute lymphoblastic leukemia treated with imatinib (STI-571).

1 reference

12 December 2020

A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors

1 reference

12 December 2020

Effect of bioflavonoids on vincristine transport across blood-brain barrier.

1 reference

12 December 2020

GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats

1 reference

12 December 2020

Alkylating activity in serum, urine, and CSF following high-dose ifosfamide in children.

1 reference

12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of imatinib after administration to nonhuman primates

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12 December 2020

Drug delivery to the brain

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12 December 2020

Pharmacokinetics of vincristine in the cerebrospinal fluid of subhuman primates

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12 December 2020

A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

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12 December 2020

A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma.

1 reference

12 December 2020

Pharmacokinetics of intraventricular and intravenous N,N',N''-triethylenethiophosphoramide (thiotepa) in rhesus monkeys and humans.

1 reference

12 December 2020

The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

1 reference

12 December 2020

Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas

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12 December 2020

Effects of a P-glycoprotein inhibitor on brain and plasma concentrations of anti-human immunodeficiency virus drugs administered in combination in rats

1 reference

12 December 2020

Methotrexate-vindesine association in leukemia: pharmacokinetic study

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12 December 2020

Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice

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12 December 2020

In vivo saturation of the transport of vinblastine and colchicine by P-glycoprotein at the rat blood-brain barrier

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12 December 2020

Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy

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12 December 2020

Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, d

1 reference

12 December 2020

Development of the brain: a vital role for cerebrospinal fluid

1 reference

12 December 2020

Temozolomide (TMZ) combined with cisplatin (CDDP) in patients with brain metastases from solid tumors: a Hellenic Cooperative Oncology Group (HeCOG) Phase II study

1 reference

12 December 2020

Plasma pharmacokinetics and cerebrospinal fluid concentrations of idarubicin and idarubicinol in pediatric leukemia patients: a Childrens Cancer Study Group report.

1 reference

12 December 2020

The effect of imatinib mesylate on patients with Philadelphia chromosome-positive chronic myeloid leukemia with secondary chromosomal aberrations.

1 reference

12 December 2020

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

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12 December 2020

The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia

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12 December 2020

Multidrug resistance transporters and modulation

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12 December 2020

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

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12 December 2020

Brain barrier systems: a new frontier in metal neurotoxicological research

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12 December 2020

Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children

1 reference

12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in nonhuman primates

1 reference

12 December 2020

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

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12 December 2020

Drug metabolism and variability among patients in drug response

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12 December 2020

Probenecid inhibition of methotrexate-cerebrospinal fluid pharmacokinetics in dogs

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12 December 2020

Pharmacokinetics of pirarubicin in plasma and cerebrospinal fluid

1 reference

12 December 2020

Multidrug resistance in cancer: role of ATP-dependent transporters

1 reference

12 December 2020

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

1 reference

12 December 2020

The effect of increasing topotecan infusion from 30 minutes to 4 hours on the duration of exposure in cerebrospinal fluid

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12 December 2020

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

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12 December 2020

Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin.

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12 December 2020

Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors

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12 December 2020

Fluoxetine and reversal of multidrug resistance

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12 December 2020

Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma.

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Drug-like properties and the causes of poor solubility and poor permeability

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12 December 2020

Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid

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12 December 2020

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

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12 December 2020

Cerebrospinal fluid concentrations of cytosine arabinoside during intravenous therapy with intermediate dose: a preliminary report

1 reference

12 December 2020

Cerebrospinal fluid concentrations of vincristine after bolus intravenous dosing: a surrogate marker of brain penetration.

1 reference

12 December 2020

Active efflux across the blood-brain barrier: role of the solute carrier family

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12 December 2020

Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.

1 reference

12 December 2020

High intratumoural accumulation of stealth liposomal doxorubicin (Caelyx) in glioblastomas and in metastatic brain tumours

1 reference

12 December 2020

10.2165/00003088-200645090-00002

Identifiers

DOI

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Dimensions Publication ID

15 August 2017

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