The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants (Q36510896)

14 August 2017

title

The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants (English)

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14 August 2017

Norbert Thuerauf

1

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14 August 2017

Jens Lunkenheimer

series ordinal

2

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14 August 2017

publication date

1 August 2006

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European Archives of Psychiatry and Clinical Neuroscience

14 August 2017

language of work or name

English

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published in

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14 August 2017

volume

256

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14 August 2017

issue

5

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14 August 2017

page(s)

287-293

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publication type of scholarly work

14 August 2017

review article

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Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study

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Fluoxetine and norfluoxetine are potent inhibitors of P450IID6--the source of the sparteine/debrisoquine oxidation polymorphism

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Maprotiline treatment in depression. A perspective on seizures

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Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine

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Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio

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Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain

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Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin

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12 December 2020

Clomipramine dose-effect study in patients with depression: clinical end points and pharmacokinetics. Danish University Antidepressant Group (DUAG)

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Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

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Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment

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CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study

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12 December 2020

Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers

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Fluvoxamine-tricyclic antidepressant interaction

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Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro.

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The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine

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Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjects

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The emerging role of cytochrome P450 3A in psychopharmacology

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Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes*

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12 December 2020

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6

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12 December 2020

Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection

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12 December 2020

Steady State Concentrations of the Enantiomers of Mianserin and Desmethylmianserin in Poor and in Homozygous and Heterozygous Extensive Metabolizers of Debrisoquine

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12 December 2020

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

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12 December 2020

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

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12 December 2020

The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer

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Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites

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Bupropion plasma levels and CYP2D6 phenotype

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12 December 2020

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

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12 December 2020

Relationship between fluvoxamine pharmacokinetics and CYP2D6/CYP2C19 phenotype polymorphisms

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12 December 2020

Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding

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12 December 2020

CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages

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Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms

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Studies on the Stereoselective Metabolism of Citalopram by Human Liver Microsomes and cDNA-Expressed Cytochrome P450 Enzymes

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Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine

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Metabolism of trimipramine in vitro by human CYP2D6 isozyme

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Carbamazepine but not valproate induces bupropion metabolism

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12 December 2020

Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression

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12 December 2020

Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans

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12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

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12 December 2020

Paroxetine plasma levels: lack of correlation with efficacy or adverse events

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12 December 2020

Imipramine metabolism in relation to the sparteine oxidation polymorphism - a family study

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12 December 2020

Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan

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12 December 2020

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

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12 December 2020

Pharmacokinetics and metabolism of trazodone in man (author's transl)

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12 December 2020

The CYP2D6 Genotype and Plasma Concentrations of Mianserin Enantiomers in Relation to Therapeutic Response to Mianserin in Depressed Japanese Patients

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12 December 2020

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

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12 December 2020

Importance of oxidative polymorphism on clinical efficacy and side-effects of imipramine--a retrospective study

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12 December 2020

Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype

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12 December 2020

Trazodone treatment increases plasma prolactin concentrations in depressed patients.

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12 December 2020

Antidepressants and drug-metabolizing enzymes--expert group report

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12 December 2020

Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants

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12 December 2020

Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine

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12 December 2020

Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes

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12 December 2020

Second-Generation Antidepressants

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12 December 2020

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

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12 December 2020

Quantitation of trimipramine enantiomers in human serum by enantioselective high-performance liquid chromatography and mixed-mode disc solid-phase extraction

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12 December 2020

Nonlinear pharmacokinetics of chlorimipramine after infusion and oral administration in patients

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12 December 2020

Inhibition of trazodone metabolism by thioridazine in humans

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12 December 2020

Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity

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12 December 2020

Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers

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12 December 2020

Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolites

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12 December 2020

Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects

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12 December 2020

The relationship between paroxetine and the sparteine oxidation polymorphism

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12 December 2020

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

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12 December 2020

Metabolic interaction between tricyclic antidepressant and fluvoxamine and fluoxetine, a pharmacogenetic approach

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12 December 2020

Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients

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12 December 2020

Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin

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12 December 2020

Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo

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12 December 2020

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

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12 December 2020

Non‐linear fluvoxamine disposition

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12 December 2020

Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms

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12 December 2020

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man

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12 December 2020

Amitriptyline metabolism: relationship to polymorphic debrisoquine hydroxylation

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12 December 2020

Isolation and identification of hydroxylated maprotiline metabolites

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12 December 2020

Non-response to maprotiline caused by ultra-rapid metabolism that is different from CYP2D6?

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12 December 2020

Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group

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12 December 2020

Biotransformation of moclobemide in humans

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12 December 2020

Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo

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12 December 2020

Monitoring tricyclic antidepressants

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12 December 2020

10.1007/S00406-006-0663-5

Identifiers

DOI

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14 August 2017

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