Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor. (Q36483829)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23151510%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor (English)

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17 February 2020

2

1 reference

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17 February 2020

Søren G. F. Rasmussen

series ordinal

3

1 reference

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17 February 2020

Daniel Jobst Muller

series ordinal

5

1 reference

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17 February 2020

4

Brian K Kobilka

1 reference

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17 February 2020

author name string

Michael Zocher

series ordinal

1

1 reference

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17 February 2020

language of work or name

English

0 references

publication date

14 November 2012

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

17 February 2020

published in

1 reference

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17 February 2020

volume

109

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17 February 2020

page(s)

E3463-72

1 reference

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17 February 2020

issue

50

1 reference

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Membrane cholesterol stabilizes the human serotonin(1A) receptor

17 February 2020

cites work

1 reference

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Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor

30 September 2017

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Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

30 September 2017

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Locating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetP.

30 September 2017

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex

30 September 2017

1 reference

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

30 September 2017

1 reference

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Dual energy landscape: the functional state of the β-barrel outer membrane protein G molds its unfolding energy landscape

30 September 2017

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Conservation of molecular interactions stabilizing bovine and mouse rhodopsin

30 September 2017

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30 September 2017

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Revitalizing membrane rafts: new tools and insights

30 September 2017

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Lipid rafts as a membrane-organizing principle

30 September 2017

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Subcellular targeting strategies for drug design and delivery

30 September 2017

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Emerging roles for lipids in shaping membrane-protein function.

30 September 2017

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Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter.

30 September 2017

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Theory, analysis, and interpretation of single-molecule force spectroscopy experiments

30 September 2017

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Dopamine D2 receptors form higher order oligomers at physiological expression levels

30 September 2017

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Role of extracellular glutamic acids in the stability and energy landscape of bacteriorhodopsin

30 September 2017

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AFM: a nanotool in membrane biology

30 September 2017

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

30 September 2017

1 reference

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Structure and mechanics of membrane proteins

30 September 2017

1 reference

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From valleys to ridges: exploring the dynamic energy landscape of single membrane proteins.

30 September 2017

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Point mutations in membrane proteins reshape energy landscape and populate different unfolding pathways

30 September 2017

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

30 September 2017

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

30 September 2017

1 reference

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

30 September 2017

1 reference

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Conformational complexity of G-protein-coupled receptors

30 September 2017

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Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy.

30 September 2017

1 reference

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Fluctuations of primary ubiquitin folding intermediates in a force clamp

30 September 2017

1 reference

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Stabilizing effect of Zn2+ in native bovine rhodopsin

30 September 2017

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How many drug targets are there?

30 September 2017

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Anisotropic deformation response of single protein molecules.

30 September 2017

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The experimental survey of protein-folding energy landscapes

30 September 2017

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Role of cholesterol in the function and organization of G-protein coupled receptors.

30 September 2017

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GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

30 September 2017

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DrugBank: a comprehensive resource for in silico drug discovery and exploration

30 September 2017

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Membranes are more mosaic than fluid

30 September 2017

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Exploring the energy landscape of GFP by single-molecule mechanical experiments

30 September 2017

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How lipids affect the activities of integral membrane proteins

30 September 2017

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G protein-coupled receptor dimerization: function and ligand pharmacology

30 September 2017

1 reference

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Roles of G-protein-coupled receptor dimerization

30 September 2017

1 reference

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Unfolding pathways of native bacteriorhodopsin depend on temperature.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528585

The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528585

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

30 September 2017

1 reference

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Stability of bacteriorhodopsin alpha-helices and loops analyzed by single-molecule force spectroscopy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528585

Cholesterol as stabilizer of the oxytocin receptor.

30 September 2017

1 reference

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Identification of G protein-coupled receptor genes from the human genome sequence

30 September 2017

1 reference

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Probing the relation between force--lifetime--and chemistry in single molecular bonds

30 September 2017

1 reference

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Regulation of receptor function by cholesterol.

30 September 2017

1 reference

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Folding and binding cascades: dynamic landscapes and population shifts

30 September 2017

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Cholesterol as modulator of receptor function.

30 September 2017

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Dynamic strength of molecular adhesion bonds

30 September 2017

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Do receptors get pregnant too? Adrenergic receptor alterations in human pregnancy

30 September 2017

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A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

30 September 2017

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Beta-adrenoceptors on smooth muscle, nerves and inflammatory cells

30 September 2017

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Entropic elasticity of lambda-phage DNA

30 September 2017

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ESR spin-label studies of lipid-protein interactions in membranes

30 September 2017

1 reference

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Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

30 September 2017

1 reference

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Elastic deformation and failure of lipid bilayer membranes containing cholesterol

30 September 2017

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Beta 2 adrenergic receptors in asthma: a current perspective

30 September 2017

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Rhodopsin-lipid associations in bovine rod outer segment membranes. Identification of immobilized lipid by spin-labels

30 September 2017

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Fully automated single-molecule force spectroscopy for screening applications.

30 September 2017

1 reference

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Probing the interactions of carboxy-atractyloside and atractyloside with the yeast mitochondrial ADP/ATP carrier.

28 June 2018

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G protein-coupled receptors. II. Mechanism of agonist activation.

28 June 2018

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Interaction of the beta-adrenergic receptor with Gs following delipidation. Specific lipid requirements for Gs activation and GTPase function

28 June 2018

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The role of cholesterol on the activity and stability of neurotensin receptor 1.

28 June 2018

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Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer

21 September 2018

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Examining the dynamic energy landscape of an antiporter upon inhibitor binding

21 September 2018

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Cholesterol modulates ligand binding and G-protein coupling to serotonin(1A) receptors from bovine hippocampus.

21 September 2018

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Probing the energy landscape of the membrane protein bacteriorhodopsin.

21 September 2018

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Dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding.

21 September 2018

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Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes

21 September 2018

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Lipid-lipid and lipid-protein interactions in chromaffin granule membranes. A spin label ESR study.

21 September 2018

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Atomic force microscopy and spectroscopy of native membrane proteins

21 September 2018

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Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles

4 December 2018

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12 December 2020

Why are there so many adrenoceptor subtypes?

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12 December 2020

Reversible unfolding of individual titin immunoglobulin domains by AFM

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12 December 2020

Membrane cholesterol modulates galanin-GalR2 interaction

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12 December 2020

Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamic force spectroscopy

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12 December 2020

Giant vesicle bilayers composed of mixtures of lipids, cholesterol and polypeptides. Thermomechanical and (mutual) adherence properties

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12 December 2020

Delipidation of a beta-adrenergic receptor preparation and reconstitution by specific lipids

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1210373109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23151510%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23151510%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23151510%20AND%20SRC:MED&resulttype=core&format=json