Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease. (Q36480706)

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English	Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.	scientific article

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21 February 2020

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease (English)

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21 February 2020

Huntington's disease

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neurophysiology

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based on heuristic

inferred from title

magnetic resonance imaging

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behavioural change

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inferred from title

Kimmo K Lehtimäki

2

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Taneli Heikkinen

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Nina Vartiainen

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Jukka Puoliväli

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Susan J Hendricks

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Jack R Glaser

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Amyaouch Bradaia

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Kristian Wadel

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Chrystelle Touller

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Outi Kontkanen

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Juha M Yrjänheikki

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Bruno Buisson

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David Howland

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Ignacio Munoz-Sanjuan

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Larry C Park

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20 December 2012

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e50717

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Creative Commons Attribution 4.0 International

20 December 2012

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

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Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

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Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

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Development of biomarkers for Huntington's disease

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30 September 2017

Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease

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30 September 2017

Cognitive functions and corticostriatal circuits: insights from Huntington's disease.

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Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

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Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease

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Corticostriatal dysfunction underlies diminished striatal ascorbate release in the R6/2 mouse model of Huntington's disease

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Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

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30 September 2017

Dysregulated information processing by medium spiny neurons in striatum of freely behaving mouse models of Huntington's disease

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Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

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Detection of Huntington's disease decades before diagnosis: the Predict-HD study

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Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy

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Oxidative damage in Huntington's disease pathogenesis

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N-acetylaspartate: a literature review of animal research on brain ischaemia.

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Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

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30 September 2017

Striatal volume loss in HD as measured by MRI and the influence of CAG repeat

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30 September 2017

Clinical correlation of striatal 1H MRS changes in Huntington's disease

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30 September 2017

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

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30 September 2017

Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats

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30 September 2017

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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30 September 2017

Corticostriatal and thalamostriatal synapses have distinctive properties

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28 June 2018

Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease.

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28 June 2018

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

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28 June 2018

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

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28 June 2018

The efficiency of systematic sampling in stereology--reconsidered.

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28 June 2018

Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases

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28 June 2018

Frontal lobe volume in patients with Huntington's disease

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28 June 2018

Single photon emission computed tomographic blood flow and magnetic resonance volume imaging of basal ganglia in Huntington's disease

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28 June 2018

Trinucleotide repeat elongation in the Huntingtin gene in Huntington disease patients from 71 Danish families

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28 June 2018

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

1 reference

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21 September 2018

Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington's Disease

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21 September 2018

Cortical and thalamic innervation of direct and indirect pathway medium-sized spiny neurons in mouse striatum.

1 reference

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21 September 2018

Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease

1 reference

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21 September 2018

Weight loss in Huntington disease increases with higher CAG repeat number

1 reference

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21 September 2018

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

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21 September 2018

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

1 reference

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21 September 2018

Striatal potassium channel dysfunction in Huntington's disease transgenic mice

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21 September 2018

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

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21 September 2018

Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

1 reference

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21 September 2018

Ideomotor limb apraxia in Huntington's disease: implications for corticostriate involvement

1 reference

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21 September 2018

Regional and progressive thinning of the cortical ribbon in Huntington's disease

1 reference

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21 September 2018

Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach.

1 reference

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21 September 2018

Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease

1 reference

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21 September 2018

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10.1371/JOURNAL.PONE.0050717

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