Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175. (Q34531481)

2 August 2017

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175. (English)

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2 August 2017

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Liliana B Menalled

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2 August 2017

Andrea E Kudwa

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2 August 2017

Sam Miller

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2 August 2017

Jon Fitzpatrick

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2 August 2017

Judy Watson-Johnson

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Nicole Keating

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Melinda Ruiz

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Richard Mushlin

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William Alosio

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Kristi McConnell

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David Connor

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Carol Murphy

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2 August 2017

Steve Oakeshott

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Mei Kwan

14

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2 August 2017

Jose Beltran

15

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2 August 2017

Afshin Ghavami

16

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2 August 2017

Dani Brunner

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2 August 2017

Larry C Park

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2 August 2017

Sylvie Ramboz

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2 August 2017

David Howland

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2 August 2017

language of work or name

English

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publication date

20 December 2012

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2 August 2017

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7

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e49838

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2 August 2017

12

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Creative Commons Attribution 4.0 International

2 August 2017

start time

20 December 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats

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Early autophagic response in a novel knock-in model of Huntington disease

7 July 2018

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Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

7 July 2018

1 reference

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Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

7 July 2018

1 reference

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Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease

7 July 2018

1 reference

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Knock-in mouse models of Huntington's disease

7 July 2018

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The use of transgenic and knock-in mice to study Huntington's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Mouse models of Huntington's disease

7 July 2018

1 reference

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Coordination of prehensile forces during precision grip in Huntington's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Duration of illness in Huntington's disease is not related to age at onset

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Body weight and dietary factors in Huntington's disease patients compared with matched controls

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Neuropathological classification of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Preproenkephalin messenger RNA?containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Transgenic rat model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Disturbances of precision grip in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

A retrospective study of the impact of lifestyle on age at onset of Huntington disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Delaying the onset of Huntington's in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049838

Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527464

10.1371/JOURNAL.PONE.0049838

27 October 2018

Identifiers

DOI

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2 August 2017

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2 August 2017

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