Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations (Q36435501)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861357%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations (English)

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14 February 2020

5

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14 February 2020

author name string

H Hamlet Chu

1

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14 February 2020

James J Moon

2

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14 February 2020

Andrew C Kruse

3

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14 February 2020

Marion Pepper

4

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14 February 2020

language of work or name

English

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publication date

22 September 2010

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14 February 2020

published in

Journal of Immunology

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14 February 2020

volume

185

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14 February 2020

issue

8

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14 February 2020

page(s)

4705-4713

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Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

14 February 2020

cites work

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30 September 2017

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Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

30 September 2017

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30 September 2017

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An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

30 September 2017

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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

30 September 2017

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Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire

30 September 2017

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30 September 2017

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The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion

30 September 2017

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Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice

30 September 2017

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Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

30 September 2017

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Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance

30 September 2017

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Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection

30 September 2017

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Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

30 September 2017

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Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

30 September 2017

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Disulfide bond engineering to trap peptides in the MHC class I binding groove

30 September 2017

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Structural determinants of T-cell receptor bias in immunity

30 September 2017

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Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses

30 September 2017

1 reference

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How TCRs bind MHCs, peptides, and coreceptors

30 September 2017

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Naive and memory CD4+ T cell survival controlled by clonal abundance

30 September 2017

1 reference

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Central tolerance: learning self-control in the thymus

30 September 2017

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Structural and kinetic basis for heightened immunogenicity of T cell vaccines

30 September 2017

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CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

30 September 2017

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A structural basis for immunodominant human T cell receptor recognition

30 September 2017

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Positive and negative selection of T cells

30 September 2017

1 reference

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Alternate interactions define the binding of peptides to the MHC molecule IA(b).

30 September 2017

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Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium

30 September 2017

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An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro

30 September 2017

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Cation-pi interactions in structural biology

30 September 2017

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Antigen presentation and T cell development in H2-M-deficient mice

30 September 2017

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H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

30 September 2017

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Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

30 September 2017

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Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice

30 September 2017

1 reference

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T-cell antigen receptor genes and T-cell recognition

30 September 2017

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Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

30 September 2017

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A novel MHC class II epitope expressed in thymic medulla but not cortex

30 September 2017

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Production of soluble MHC class II proteins with covalently bound single peptides

30 September 2017

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Positive selection of CD4+ T cells mediated by MHC class II-bearing stromal cell in the thymic cortex.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses.

21 September 2018

1 reference

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Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

The repertoire of T cells shaped by a single MHC/peptide ligand.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

How the T Cell Repertoire Becomes Peptide and MHC Specific

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510669

Impact of TCR reactivity and HLA phenotype on naive CD8 T cell frequency in humans

4 December 2018

1 reference

12 December 2020

DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope

1 reference

12 December 2020

Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice

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12 December 2020

On the complexity of self

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12 December 2020

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

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12 December 2020

Identification of a naturally occurring ligand for thymic positive selection

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12 December 2020

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1002276

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861357%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861357%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference