Central tolerance: learning self-control in the thymus (Q28275215)

Nature Reviews Immunology

Europe PubMed Central

title

Central tolerance: learning self-control in the thymus (English)

0 references

0 references

Stephen C Jameson

3

0 references

Kristin A. Hogquist

object named as

Kristin A Hogquist

series ordinal

1

0 references

author name string

Troy A Baldwin

series ordinal

2

0 references

language of work or name

English

0 references

publication date

October 2005

0 references

published in

0 references

volume

5

0 references

issue

10

0 references

page(s)

772-82

0 references

cites work

Negative selection--clearing out the bad apples from the T-cell repertoire

1 reference

Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen

21 January 2018

1 reference

Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.

21 January 2018

1 reference

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

21 January 2018

1 reference

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

21 January 2018

1 reference

Starting at the beginning: new perspectives on the biology of mucosal T cells

21 January 2018

1 reference

Lymphotoxin alpha 1 beta 2: a critical mediator in V alpha 14i NKT cell differentiation

21 January 2018

1 reference

The fourth way? Harnessing aggressive tendencies in the thymus

21 January 2018

1 reference

AIRE and APECED: molecular insights into an autoimmune disease

21 January 2018

1 reference

Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

21 January 2018

1 reference

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

1 reference

Negative selection of thymocytes expressing the D10 TCR

21 January 2018

1 reference

The timing of TCR alpha expression critically influences T cell development and selection

21 January 2018

1 reference

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

21 January 2018

1 reference

Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus.

21 January 2018

1 reference

T cell tolerance by clonal elimination in the thymus

21 January 2018

1 reference

Rules for gene usage inferred from a comparison of large-scale gene expression profiles of T and B lymphocyte development.

21 January 2018

1 reference

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

21 January 2018

1 reference

Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation

21 January 2018

1 reference

Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

21 January 2018

1 reference

CCR7 signals are essential for cortex-medulla migration of developing thymocytes.

21 January 2018

1 reference

CCR7 directs the migration of thymocytes into the thymic medulla

21 January 2018

1 reference

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

21 January 2018

1 reference

Expression of relB is required for the development of thymic medulla and dendritic cells

21 January 2018

1 reference

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

21 January 2018

1 reference

Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

21 January 2018

1 reference

Lymphotoxin pathway directs thymic Aire expression

21 January 2018

1 reference

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

21 January 2018

1 reference

NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells

21 January 2018

1 reference

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

21 January 2018

1 reference

Development and maturation of secondary lymphoid tissues.

21 January 2018

1 reference

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

21 January 2018

1 reference

Cross-presentation in viral immunity and self-tolerance.

21 January 2018

1 reference

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

21 January 2018

1 reference

A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection

21 January 2018

1 reference

Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells

21 January 2018

1 reference

An essential role for gp39, the ligand for CD40, in thymic selection.

21 January 2018

1 reference

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

1 reference

CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.

21 January 2018

1 reference

Self-representation in the thymus: an extended view

21 January 2018

1 reference

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

1 reference

Positional cloning of the APECED gene

21 January 2018

1 reference

Aire regulates negative selection of organ-specific T cells

21 January 2018

1 reference

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

21 January 2018

1 reference

21 January 2018

1 reference

Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain

21 January 2018

1 reference

The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

21 January 2018

1 reference

Contrasting models of promiscuous gene expression by thymic epithelium

21 January 2018

1 reference

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

21 January 2018

1 reference

Chromosomal clustering of genes controlled by the aire transcription factor

21 January 2018

1 reference

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

21 January 2018

1 reference

AIRE functions as an E3 ubiquitin ligase

21 January 2018

1 reference

NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease

21 January 2018

1 reference

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

21 January 2018

1 reference

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

21 January 2018

1 reference

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

1 reference

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

1 reference

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection

21 January 2018

1 reference

A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

21 January 2018

1 reference

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

21 January 2018

1 reference

The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function

21 January 2018

1 reference

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

21 January 2018

1 reference

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

21 January 2018

1 reference

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

21 January 2018

1 reference

Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor

21 January 2018

1 reference

The control of apoptosis in lymphocyte selection

21 January 2018

1 reference

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

21 January 2018

1 reference

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

1 reference

Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

21 January 2018

1 reference

Generation of NK1.1+ T cell antigen receptor alpha/beta+ thymocytes associated with intact thymic structure

21 January 2018

1 reference

Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development

21 January 2018

1 reference

The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

1 reference

CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice

21 January 2018

1 reference

T-cell apoptosis detected in situ during positive and negative selection in the thymus

21 January 2018

1 reference

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

21 January 2018

1 reference

Receptor editing in developing T cells

21 January 2018

1 reference

Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

31 March 2020

1 reference

The regulated expression of a diverse set of genes during thymocyte positive selection in vivo

31 March 2020

1 reference

Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development

31 March 2020

1 reference

T Cell Development in Mice Expressing CD1d Directed by a Classical MHC Class II Promoter

31 March 2020

1 reference

Defective central tolerance induction in NOD mice: genomics and genetics

31 March 2020

1 reference

A defect in central tolerance in NOD mice

31 March 2020

1 reference

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

31 March 2020

1 reference

RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells

31 March 2020

1 reference