Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1 (Q36413835)

14 August 2017

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1 (English)

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14 August 2017

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Wen-Ying Lee

1

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14 August 2017

Wai-Theng Lee

2

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14 August 2017

Chia-Hsiung Cheng

3

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14 August 2017

Ku-Chung Chen

4

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14 August 2017

Chih-Ming Chou

5

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14 August 2017

Chu-Hung Chung

6

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14 August 2017

Min-Siou Sun

7

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14 August 2017

Hung-Wei Cheng

8

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14 August 2017

Meng-Ni Ho

9

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14 August 2017

Cheng-Wei Lin

10

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14 August 2017

language of work or name

English

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publication date

5 September 2015

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14 August 2017

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14 August 2017

6

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14 August 2017

29

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14 August 2017

27580-27595

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4695010/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients

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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

30 September 2017

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30 September 2017

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SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation

30 September 2017

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30 September 2017

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Mutant p53 in cancer: new functions and therapeutic opportunities

30 September 2017

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30 September 2017

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The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells

30 September 2017

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Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents

30 September 2017

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Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

30 September 2017

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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases

30 September 2017

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Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2

30 September 2017

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Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo.

30 September 2017

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Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer.

30 September 2017

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Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth

30 September 2017

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Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

30 September 2017

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AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.

30 September 2017

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Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

30 September 2017

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A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.

30 September 2017

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Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer

30 September 2017

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Metformin: multi-faceted protection against cancer

30 September 2017

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Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.

30 September 2017

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Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma

30 September 2017

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SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer

30 September 2017

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SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

30 September 2017

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Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity

30 September 2017

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Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation.

30 September 2017

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The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

30 September 2017

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SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

30 September 2017

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Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells

30 September 2017

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JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

30 September 2017

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Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

30 September 2017

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Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.

30 September 2017

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Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

30 September 2017

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The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells

30 September 2017

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p53 acetylation is crucial for its transcription-independent proapoptotic functions

30 September 2017

1 reference

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Phosphorylation regulates SIRT1 function.

30 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

Targeting the MDM2-p53 interaction for cancer therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

Acetylation is indispensable for p53 activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress

30 September 2017

1 reference

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

30 September 2017

1 reference

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Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

30 September 2017

1 reference

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

30 September 2017

1 reference

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The functional interactions between the p53 and MAPK signaling pathways

30 September 2017

1 reference

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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

A new science-business paradigm in anticancer drug development.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

Acetylation of p53 inhibits its ubiquitination by Mdm2.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695010

21 September 2018

Identifiers

DOI

10.18632/ONCOTARGET.4768

1 reference

14 August 2017

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14 August 2017

1 reference