AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2. (Q36413704)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26318033%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

title

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2 (English)

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23 February 2020

10

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23 February 2020

author name string

Hui-Ping Lin

1

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23 February 2020

Ching-Yu Lin

2

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23 February 2020

Chieh Huo

3

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23 February 2020

Yee-Jee Jan

4

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23 February 2020

Jen-Chih Tseng

5

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23 February 2020

Shih Sheng Jiang

6

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23 February 2020

Ying-Yu Kuo

7

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23 February 2020

Shyh-Chang Chen

8

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23 February 2020

Chih-Ting Wang

9

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23 February 2020

Jun-Yang Liou

11

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23 February 2020

John Wang

12

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23 February 2020

Wun-Shaing Wayne Chang

13

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23 February 2020

Chung-Ho Chang

14

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23 February 2020

Hsing-Jien Kung

15

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23 February 2020

Chih-Pin Chuu

16

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23 February 2020

language of work or name

English

0 references

publication date

1 September 2015

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23 February 2020

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23 February 2020

volume

6

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23 February 2020

issue

29

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23 February 2020

page(s)

27097-27112

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Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.

23 February 2020

cites work

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Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2.

30 September 2017

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PTEN-deficient tumors depend on AKT2 for maintenance and survival

30 September 2017

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Difference in protein expression profile and chemotherapy drugs response of different progression stages of LNCaP sublines and other human prostate cancer cells

30 September 2017

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Cholestane-3β, 5α, 6β-triol suppresses proliferation, migration, and invasion of human prostate cancer cells

30 September 2017

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AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.

30 September 2017

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Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells

30 September 2017

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Phospho-Akt immunoreactivity in prostate cancer: relationship to disease severity and outcome, Ki67 and phosphorylated EGFR expression

30 September 2017

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The mutational landscape of lethal castration-resistant prostate cancer

30 September 2017

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Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks

30 September 2017

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Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells

30 September 2017

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Skp2: a novel potential therapeutic target for prostate cancer

30 September 2017

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Androgen suppresses proliferation of castration-resistant LNCaP 104-R2 prostate cancer cells through androgen receptor, Skp2, and c-Myc

30 September 2017

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Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines

30 September 2017

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Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice

30 September 2017

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Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo.

30 September 2017

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Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2

30 September 2017

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Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

30 September 2017

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Targeting the PI3K/AKT pathway for the treatment of prostate cancer

30 September 2017

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Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

30 September 2017

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Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

30 September 2017

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BRAF activation initiates but does not maintain invasive prostate adenocarcinoma

30 September 2017

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Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells

30 September 2017

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Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients.

30 September 2017

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Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase

30 September 2017

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Modulation of liver X receptor signaling as novel therapy for prostate cancer

30 September 2017

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30 September 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

30 September 2017

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Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP).

30 September 2017

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Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist

30 September 2017

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Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions

30 September 2017

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Androgen causes growth suppression and reversion of androgen-independent prostate cancer xenografts to an androgen-stimulated phenotype in athymic mice

30 September 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

30 September 2017

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TSC2: filling the GAP in the mTOR signaling pathway

30 September 2017

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Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

30 September 2017

1 reference

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The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

30 September 2017

1 reference

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

30 September 2017

1 reference

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Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

30 September 2017

1 reference

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

30 September 2017

1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

30 September 2017

1 reference

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30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Isolation of a human prostate carcinoma cell line (DU 145)

30 September 2017

1 reference

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Establishment and characterization of a human prostatic carcinoma cell line (PC-3)

30 September 2017

1 reference

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Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA.

30 September 2017

1 reference

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PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4694976

Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26318033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.4553

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26318033%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26318033%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

26318033

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26318033%20AND%20SRC:MED&resulttype=core&format=json