Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity (Q36394952)

13 August 2017

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity (English)

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13 August 2017

1 reference

1 reference

Christopher M William

object named as

Christopher M William

11

0 references

Tara L Spires-Jones

object named as

Tara L Spires-Jones

12

0 references

Bradley Hyman

16

object named as

Bradley T Hyman

1 reference

13 August 2017

15

Amy M Pooler

1 reference

13 August 2017

9

Shuko Takeda

1 reference

13 August 2017

1

Susanne Wegmann

1 reference

13 August 2017

13

Rose Pitstick

1 reference

13 August 2017

14

George A Carlson

1 reference

13 August 2017

8

Zhanyun Fan

1 reference

13 August 2017

5

Allyson Roe

1 reference

13 August 2017

7

Samantha Nicholls

1 reference

13 August 2017

4

Lubna Saqran

1 reference

13 August 2017

10

Ozge Cagsal-Getkin

1 reference

13 August 2017

Eduardo A Maury

2

1 reference

13 August 2017

Molly J Kirk

3

1 reference

13 August 2017

Sarah L DeVos

6

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13 August 2017

language of work or name

English

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publication date

4 November 2015

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13 August 2017

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13 August 2017

34

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13 August 2017

3028-3041

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13 August 2017

24

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4687785/fullTextXML

inferred from PubMed Central ID database lookup

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Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex

30 September 2017

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Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses

30 September 2017

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30 September 2017

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Antisense reduction of tau in adult mice protects against seizures

30 September 2017

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Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology

30 September 2017

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Mechanisms of protein seeding in neurodegenerative diseases

30 September 2017

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

30 September 2017

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Soluble forms of tau are toxic in Alzheimer's disease

30 September 2017

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Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits

30 September 2017

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The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

30 September 2017

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Lessons from tau-deficient mice

30 September 2017

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Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration.

30 September 2017

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Propagation of tau pathology in a model of early Alzheimer's disease

30 September 2017

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Trans-synaptic spread of tau pathology in vivo

30 September 2017

1 reference

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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

30 September 2017

1 reference

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Neuropathological alterations in Alzheimer disease

30 September 2017

1 reference

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

30 September 2017

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

30 September 2017

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Caspase activation precedes and leads to tangles

30 September 2017

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

30 September 2017

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

30 September 2017

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Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

30 September 2017

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Transgenic models of Alzheimer's disease: learning from animals

30 September 2017

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Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

30 September 2017

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Tau suppression in a neurodegenerative mouse model improves memory function

30 September 2017

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Tau is essential to beta -amyloid-induced neurotoxicity

30 September 2017

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Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.

30 September 2017

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Neurodegenerative tauopathies

30 September 2017

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Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system

30 September 2017

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Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

30 September 2017

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CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

30 September 2017

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A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

30 September 2017

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Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

30 September 2017

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Neuropathological stageing of Alzheimer-related changes

30 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Distinct tau prion strains propagate in cells and mice and define different tauopathies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Silver staining of Alzheimer's neurofibrillary changes by means of physical development.

28 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

[Induction and spreading of tau pathology in a mouse model of Alzheimer's disease].

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

CaMKII activation in the entorhinal cortex disrupts previously encoded spatial memory.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Neurotrophins are required for nerve growth during development.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Normal host prion protein necessary for scrapie-induced neurotoxicity.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687785

Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26538322

12 December 2020

inferred from PubMed ID database lookup

Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26538322

12 December 2020

inferred from PubMed ID database lookup

Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26538322

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.15252/EMBJ.201592748

1 reference

13 August 2017

1 reference

13 August 2017

1 reference