Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning (Q36393842)

15 June 2018

title

Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning (English)

1 reference

15 June 2018

main subject

deep mutational scanning

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author name string

Patrick Koenig

1

1 reference

15 June 2018

Sarah Sanowar

2

1 reference

15 June 2018

Chingwei V Lee

3

1 reference

15 June 2018

Germaine Fuh

4

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15 June 2018

publication date

6 June 2017

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15 June 2018

published in

Monoclonal Antibodies

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15 June 2018

volume

9

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15 June 2018

page(s)

959-967

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15 June 2018

issue

6

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15 June 2018

Biophysical properties of the clinical-stage antibody landscape.

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A two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions

28 June 2018

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28 June 2018

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28 June 2018

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Structural basis for angiopoietin-1-mediated signaling initiation

28 June 2018

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Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

28 June 2018

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28 June 2018

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Angiopoietins in angiogenesis

28 June 2018

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Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

28 June 2018

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A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies

28 June 2018

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Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4.

28 June 2018

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Evolving concepts of specificity in immune reactions

28 June 2018

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Exploiting cross-reactivity to neutralize two different scorpion venoms with one single chain antibody fragment

28 June 2018

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High-resolution mapping of protein sequence-function relationships

28 June 2018

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Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent

28 June 2018

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28 June 2018

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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

28 June 2018

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Improving antibody binding affinity and specificity for therapeutic development

28 June 2018

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Lack of specificity of commercially available antisera against muscarinergic and adrenergic receptors

28 June 2018

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

28 June 2018

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Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin

28 June 2018

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28 June 2018

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Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

28 June 2018

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A general method for greatly improving the affinity of antibodies by using combinatorial libraries

28 June 2018

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Fine tuning of the specificity of an anti-progesterone antibody by first and second sphere residue engineering

28 June 2018

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28 June 2018

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High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold

28 June 2018

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Modulating the binding properties of an anti‐17β‐estradiol antibody by systematic mutation combinations

28 June 2018

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Further improvement of broad specificity hapten recognition with protein engineering

28 June 2018

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Antibody multispecificity mediated by conformational diversity

28 June 2018

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Changes in the specificity of antibodies by site-specific mutagenesis followed by random mutagenesis

28 June 2018

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Improving the affinity and the fine specificity of an anti-cortisol antibody by parsimonious mutagenesis and phage display

28 June 2018

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CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range

28 June 2018

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The strange cross-reaction of menadione (vitamin K3) and 2,4-dinitrophenyl ligands with a myeloma protein and some conventional antibodies

28 June 2018

1 reference

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Selecting high-affinity binding proteins by monovalent phage display

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540083

A strategy for risk mitigation of antibodies with fast clearance.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540083

Improving the species cross-reactivity of an antibody using computational design

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540083

Lack of specificity of antibodies directed against human beta-adrenergic receptors.

21 September 2018

1 reference

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Selection and screening using antibody phage display libraries

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F19420862.2017.1337618

10.1080/19420862.2017.1337618

21 January 2018

Identifiers

DOI

1 reference

15 June 2018

PMCID

5540083

1 reference

15 June 2018

PubMed ID

28585908

1 reference

15 June 2018