Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation (Q36387226)

13 August 2017

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation (English)

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13 August 2017

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Arachidonate 12-lipoxygenase, 12S type

ChEBI ID

90773

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GOA release 2020-03-11

fatty acid oxidation

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GOA release 2020-03-11

author name string

Kenneth N Ikei

1

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13 August 2017

Jennifer Yeung

2

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13 August 2017

Patrick L Apopa

3

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13 August 2017

Jesús Ceja

4

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13 August 2017

Joanne Vesci

5

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13 August 2017

Theodore R Holman

6

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13 August 2017

Michael Holinstat

7

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13 August 2017

13 September 2012

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Journal of Lipid Research

13 August 2017

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13 August 2017

53

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13 August 2017

2546-2559

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13 August 2017

12

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Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation

13 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

12-lipoxygenase: a potential target for novel anti-platelet therapeutics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Molecular enzymology of lipoxygenases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Phospholipase A2 biochemistry

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

A molecular switch that controls cell spreading and retraction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Gamma linolenic acid: an antiinflammatory omega-6 fatty acid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Electrospray ionization and tandem mass spectrometry of eicosanoids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

12-lipoxygenase in porcine coronary microcirculation: implications for coronary vasoregulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Lipoxygenase inhibitors as potential cancer chemopreventives

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Importance of dietary gamma-linolenic acid in human health and nutrition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Role of lipoxygenases in breast cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Lipoxin biosynthesis and its impact in inflammatory and vascular events

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Therapeutic impact of eicosanoids in atherosclerotic disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

12-HETE inhibits the binding of PGH2/TxA2 receptor ligands in human platelets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Metabolism of 8,11,14-eicosatrienoic acid in human platelets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Antithrombotic potential of dihomo-gamma-linolenic acid in man

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

New insights from spectroscopy into the structure/function relationships of lipoxygenases

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Dihomogammalinolenic acid, but not eicosapentaenoic acid, activates washed human platelets

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Preparation and purification of soybean lipoxygenase-derived unsaturated hydroperoxy and hydroxy fatty acids and determination of molar absorptivities of hydroxy fatty acids

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. II. Effects of vitamin C

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. bark.

28 June 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Measurement of GTP-bound Ras-like GTPases by activation-specific probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M026385

THE ENZYMATIC CONVERSION OF ESSENTIAL FATTY ACIDS INTO PROSTAGLANDINS

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Effects of supplementation with fish oil-derived n-3 fatty acids and gamma-linolenic acid on circulating plasma lipids and fatty acid profiles in women.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Platelet lipoxygenase inhibitors attenuate thrombin- and thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494251

Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans

21 September 2018

1 reference

12 December 2020

Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice

1 reference

12 December 2020

Summary of the scientific conference on dietary fatty acids and cardiovascular health: conference summary from the nutrition committee of the American Heart Association

1 reference

12 December 2020

Spontaneously hypertensive rats: eicosa-8,11,14-trienoic acid metabolism and arachidonic acid biosynthesis

1 reference

12 December 2020

Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: Pharmacological basis for a therapeutic approach

1 reference

12 December 2020

The effect of borage oil consumption on the composition of individual phospholipids in human platelets

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.M026385

1 reference

13 August 2017

1 reference

13 August 2017

1 reference