Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms (Q36338753)

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English	Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms	scientific article

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scholarly article

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Europe PubMed Central

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13 August 2017

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Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms (English)

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Europe PubMed Central

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13 August 2017

multicenter clinical trial

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based on heuristic

inferred from title

Alexander M Menzies

2

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7 June 2020

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7 June 2020

Richard Scolyer

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Richard F. Kefford

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Georgina V. Long

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Levi A Garraway

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Levi A Garraway

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Antoni Ribas

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Jürgen C Becker

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John F Thompson

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Lisa Zimmer

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Ralf Gutzmer

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Helen Gogas

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Simone M. Goldinger

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Simone M Goldinger

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Gulietta M Pupo

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Gulietta M Pupo

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Xiangju Kong

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Jeffrey A Sosman

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Dirk Schadendorf

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Douglas B Johnson

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7 June 2020

Zeynep Eroglu

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7 June 2020

Fei Ye

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7 June 2020

Shilin Zhao

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7 June 2020

Carola Berking

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Friederike Egberts

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Carmen Loquai

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Roger S Lo

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7 June 2020

Antje Sucker

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publication date

19 November 2015

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13 August 2017

European Journal of Cancer

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51

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18

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7 June 2020

2792-2799

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7 June 2020

Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Preexisting MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Combined vemurafenib and cobimetinib in BRAF-mutated melanoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: promise and challenges

1 reference

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30 September 2017

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact.

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30 September 2017

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition

1 reference

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30 September 2017

The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition

1 reference

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30 September 2017

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: a possible algorithm for clinical use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666799

30 September 2017

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

1 reference

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30 September 2017

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

1 reference

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30 September 2017

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

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30 September 2017

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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30 September 2017

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

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30 September 2017

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

1 reference

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30 September 2017

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

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30 September 2017

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

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New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

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30 September 2017

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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30 September 2017

Mutations of the BRAF gene in human cancer

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30 September 2017

PD-L1 Expression and Tumor-Infiltrating Lymphocytes Define Different Subsets of MAPK Inhibitor-Treated Melanoma Patients.

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22 September 2018

Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study

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Paradoxical oncogenesis: are all BRAF inhibitors equal?

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22 September 2018

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10.1016/J.EJCA.2015.08.022

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Europe PubMed Central

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7 June 2020

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7 June 2020

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Europe PubMed Central

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7 June 2020

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